3-trifluoromethyl-1-(2-formylphenyl)-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

Base Information

• Chemical Name: 3-trifluoromethyl-1-(2-formylphenyl)-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide
• CAS No.: 637319-11-0
• Molecular Formula: C₂₅H₁₇F₄N₃O₄S
• Molecular Weight: 531.487

Synonyms:3-trifluoromethyl-1-(2-formylphenyl)-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

Chemical Property of 3-trifluoromethyl-1-(2-formylphenyl)-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

Chemical Property:

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Technology Process of 3-trifluoromethyl-1-(2-formylphenyl)-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

There total 11 articles about 3-trifluoromethyl-1-(2-formylphenyl)-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-(2-hydroxymethyl-phenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide (637319-09-6) → 3-trifluoromethyl-1-(2-formylphenyl)-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide (637319-11-0)

Guidance literature:

With manganese(IV) oxide; In chloroform; at 20 ℃; for 48h;

DOI:10.1021/jm030212h

Reference yield:

4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione (326-90-9) → 3-trifluoromethyl-1-(2-formylphenyl)-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide (637319-11-0)

Guidance literature:

Multi-step reaction with 10 steps

1: 90 percent / glac. AcOH / 6 h / Heating

2: 100 percent / oxalyl chloride; DMF / CH₂Cl₂ / 4 h

3: 100 percent / 2 h / 20 °C

4: KMnO₄ / acetone; H₂O / 4 h / Heating

5: oxalyl chloride / CH₂Cl₂ / 2 h / 20 °C

6: 3.34 g / DMAP / CH₂Cl₂ / 18 h / 20 °C

7: 89 percent / aq. NaOH / methanol / 5 h / 20 °C

8: N-methylmorpholine / tetrahydrofuran / 1 h / -10 °C

9: 0.56 g / NaBH₄ / tetrahydrofuran; H₂O / 18 h / 20 °C

10: 81 percent / MnO₂ / CHCl₃ / 48 h / 20 °C

With 4-methyl-morpholine; dmap; manganese(IV) oxide; sodium hydroxide; sodium tetrahydroborate; potassium permanganate; oxalyl dichloride; acetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; acetone;

DOI:10.1021/jm030212h

Reference yield:

2-hydrazino-benzoic acid (5326-27-2) → 3-trifluoromethyl-1-(2-formylphenyl)-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide (637319-11-0)

Guidance literature:

Multi-step reaction with 10 steps

1: 90 percent / glac. AcOH / 6 h / Heating

2: 100 percent / oxalyl chloride; DMF / CH₂Cl₂ / 4 h

3: 100 percent / 2 h / 20 °C

4: KMnO₄ / acetone; H₂O / 4 h / Heating

5: oxalyl chloride / CH₂Cl₂ / 2 h / 20 °C

6: 3.34 g / DMAP / CH₂Cl₂ / 18 h / 20 °C

7: 89 percent / aq. NaOH / methanol / 5 h / 20 °C

8: N-methylmorpholine / tetrahydrofuran / 1 h / -10 °C

9: 0.56 g / NaBH₄ / tetrahydrofuran; H₂O / 18 h / 20 °C

10: 81 percent / MnO₂ / CHCl₃ / 48 h / 20 °C

With 4-methyl-morpholine; dmap; manganese(IV) oxide; sodium hydroxide; sodium tetrahydroborate; potassium permanganate; oxalyl dichloride; acetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; acetone;

DOI:10.1021/jm030212h

upstream raw materials:

1-(2-hydroxymethyl-phenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione

2-hydrazino-benzoic acid

2-(2-methoxycarbonylphenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid

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