(4-[3-(4-fluoro-phenyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl)-(5-piperazin-1-yl-pyridin-2-yl)-amine

Base Information

Chemical Name:(4-[3-(4-fluoro-phenyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl)-(5-piperazin-1-yl-pyridin-2-yl)-amine
CAS No.:1256962-88-5
Molecular Formula:C₂₂H₂₁FN₈
Molecular Weight:416.461
Hs Code.:

Synonyms:(4-[3-(4-fluoro-phenyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl)-(5-piperazin-1-yl-pyridin-2-yl)-amine

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Chemical Property of (4-[3-(4-fluoro-phenyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl)-(5-piperazin-1-yl-pyridin-2-yl)-amine

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Technology Process of (4-[3-(4-fluoro-phenyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl)-(5-piperazin-1-yl-pyridin-2-yl)-amine

There total 6 articles about (4-[3-(4-fluoro-phenyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl)-(5-piperazin-1-yl-pyridin-2-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 571189-16-7
4-(6-nitropyridin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester

: 1256962-88-5
(4-[3-(4-fluoro-phenyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl)-(5-piperazin-1-yl-pyridin-2-yl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 10% palladium on activated carbon; hydrogen / methanol

2.1: toluene / 16 h / 120 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.2: polymer-linked carbonate MP-resin Stratospheres SPE

With 10% palladium on activated carbon; hydrogen; trifluoroacetic acid; In methanol; dichloromethane; toluene;
DOI:10.1021/jm100571n

Reference yield:

: C₂₇H₂₉FN₈O₂

: 1256962-88-5
(4-[3-(4-fluoro-phenyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl)-(5-piperazin-1-yl-pyridin-2-yl)-amine

Guidance literature:: C₂₇H₂₉FN₈O₂; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jm100571n

Reference yield:

: 677320-70-6
4-[3-(4-fluoro-phenyl)-1H-pyrazol-4-yl]-2-methylsulfanyl-pyrimidine

: 1256962-88-5
(4-[3-(4-fluoro-phenyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl)-(5-piperazin-1-yl-pyridin-2-yl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxone / N,N-dimethyl-formamide / 1 h / 90 °C

2.1: toluene / 16 h / 120 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.2: polymer-linked carbonate MP-resin Stratospheres SPE

With oxone; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm100571n