(R)-tert-butyl 7-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 7-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.:1181690-50-5
Molecular Formula:C₂₇H₃₆N₂O₂
Molecular Weight:420.595
Hs Code.:

Synonyms:(R)-tert-butyl 7-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Chemical Property of (R)-tert-butyl 7-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Technology Process of (R)-tert-butyl 7-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 3 articles about (R)-tert-butyl 7-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenylboronic Acid

: 258515-65-0
7-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylic acid tert-butyl ester

: 1181690-50-5
(R)-tert-butyl 7-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; benzene; at 100 ℃; for 2h; Microwave irradiation;

Reference yield:

: 849519-42-2
(R)-1-[2-(4-bromo-phenyl)-ethyl]-2-methyl-pyrrolidine

: 1181690-50-5
(R)-tert-butyl 7-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 - -70 °C / Inert atmosphere

1.2: 1.5 h / -65 - 20 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; benzene / 2 h / 100 °C / Microwave irradiation

With n-butyllithium; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; hexane; water; benzene; 2.1: Suzuki Coupling;

Reference yield:

: 114369-15-2
2-(4-bromophenyl)ethyl methanesulfonate

: 1181690-50-5
(R)-tert-butyl 7-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / water; acetonitrile / 71 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 - -70 °C / Inert atmosphere

2.2: 1.5 h / -65 - 20 °C / Inert atmosphere

2.3: Inert atmosphere

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; benzene / 2 h / 100 °C / Microwave irradiation

With n-butyllithium; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; hexane; water; acetonitrile; benzene; 3.1: Suzuki Coupling;