5'-O-(4,4'-dimethoxytrityl)-5-azacytidine 2',3'-O-(cyclic thiocarbonate)

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-5-azacytidine 2',3'-O-(cyclic thiocarbonate)
• CAS No.: 107036-46-4
• Molecular Formula: C₃₀H₂₈N₄O₇S
• Molecular Weight: 588.641

Synonyms:5'-O-(4,4'-dimethoxytrityl)-5-azacytidine 2',3'-O-(cyclic thiocarbonate)

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-5-azacytidine 2',3'-O-(cyclic thiocarbonate)

Chemical Property:

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-5-azacytidine 2',3'-O-(cyclic thiocarbonate)

There total 3 articles about 5'-O-(4,4'-dimethoxytrityl)-5-azacytidine 2',3'-O-(cyclic thiocarbonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,1'-Thiocarbonyldiimidazole (6160-65-2) + 5'-O-(4,4'-dimethoxytrityl)-5-azacytidine (107036-45-3) → 5'-O-(4,4'-dimethoxytrityl)-5-azacytidine 2',3'-O-(cyclic thiocarbonate) (107036-46-4)

Guidance literature:

In acetonitrile;

DOI:10.1021/jm00388a020

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 5'-O-(4,4'-dimethoxytrityl)-5-azacytidine 2',3'-O-(cyclic thiocarbonate) (107036-46-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / pyridine

2: 90 percent / acetonitrile

With pyridine; In acetonitrile;

DOI:10.1021/jm00388a020

Reference yield:

5-azacytidine (320-67-2) → 5'-O-(4,4'-dimethoxytrityl)-5-azacytidine 2',3'-O-(cyclic thiocarbonate) (107036-46-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / pyridine

2: 90 percent / acetonitrile

With pyridine; In acetonitrile;

DOI:10.1021/jm00388a020

upstream raw materials:

1,1'-Thiocarbonyldiimidazole

5'-O-(4,4'-dimethoxytrityl)-5-azacytidine

4,4'-dimethoxytrityl chloride

5-azacytidine

Downstream raw materials:

2',3'-dideoxy-5'-O-(4,4'-dimethoxytrityl)-5-azacytidine

Imidazole-1-carbothioic acid O-{(2R,3S,5R)-5-(4-amino-2-oxo-2H-[1,3,5]triazin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester

Imidazole-1-carbothioic acid O-{(2R,3R,5S)-2-(4-amino-2-oxo-2H-[1,3,5]triazin-1-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester

5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-azacytidine

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