4-(4-benzyloxyphenyl)-7-benzyloxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 4-(4-benzyloxyphenyl)-7-benzyloxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 55708-63-9
• Molecular Formula: C₃₁H₃₁NO₃
• Molecular Weight: 465.592
• Mol file: 55708-63-9.mol

Synonyms:4-(4-benzyloxyphenyl)-7-benzyloxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property of 4-(4-benzyloxyphenyl)-7-benzyloxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-benzyloxyphenyl)-7-benzyloxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

There total 15 articles about 4-(4-benzyloxyphenyl)-7-benzyloxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-(4-benzyloxyphenyl)-7-benzyloxy-6-methoxy-2-methyl-3-oxo-1,2,3,4-tetrahydroisoquinoline (330800-28-7) → 4-(4-benzyloxyphenyl)-7-benzyloxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (55708-63-9)

Guidance literature:

With borane dimethyl sulfide tetrahydrofuran; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1021/ol0155337

Reference yield: 89.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-(4-benzyloxy-3-methoxy-phenyl)-2-(4-benzyloxy-phenyl)-ethylamine (346619-36-1) → 4-(4-benzyloxyphenyl)-7-benzyloxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (55708-63-9)

Guidance literature:

With formic acid; at 100 ℃; for 3h;

DOI:10.3987/COM-01-9167

Reference yield: 75.0%

7-Benzyloxy-4-(4-benzyloxy-phenyl)-6-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid ethyl ester (96405-83-3) → 4-(4-benzyloxyphenyl)-7-benzyloxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (55708-63-9)

Guidance literature:

With lithium aluminium tetrahydride;

upstream raw materials:

7-Benzyloxy-4-(4-benzyloxy-phenyl)-6-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid ethyl ester

diazomethane

4-(4-benzyloxyphenyl)-7-benzyloxy-6-methoxy-2-methyl-3-oxo-1,2,3,4-tetrahydroisoquinoline

formaldehyd

Downstream raw materials:

4-(4-hydroxyphenyl)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline