Technology Process of 5-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)picolinic acid
There total 19 articles about 5-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)picolinic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C28H20Cl3N3O2;
With
water; potassium hydroxide;
In
ethanol;
at 100 ℃;
for 4h;
With
hydrogenchloride;
In
water;
pH=4;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 2 h / Reflux
2.1: 4 h / 175 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
3.2: 0 - 20 °C
4.1: palladium diacetate / diethyl ether / -50 - 20 °C / Inert atmosphere
5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C
5.2: 20 °C
6.1: potassium hydroxide; water / ethanol / 4 h / 100 °C
6.2: pH 4
With
N-Bromosuccinimide; water; sodium hydride; potassium hydroxide;
palladium diacetate; dibenzoyl peroxide;
In
tetrahydrofuran; tetrachloromethane; diethyl ether; ethanol; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: water; sodium carbonate; calcium hydroxide / 4.33 h / Inert atmosphere; Reflux
2.1: triethylamine / dmap / dichloromethane / 1 h / 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
3.2: 0 - 20 °C
4.1: palladium diacetate / diethyl ether / -50 - 20 °C / Inert atmosphere
5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C
5.2: 20 °C
6.1: potassium hydroxide; water / ethanol / 4 h / 100 °C
6.2: pH 4
With
water; sodium hydride; sodium carbonate; triethylamine; potassium hydroxide; calcium hydroxide;
dmap; palladium diacetate;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
