2-(4-(4-chloro-3-(trifluoromethyl)phenoxy)-3,5-difluorophenyl)ethan-1-ol

Base Information

Chemical Name:2-(4-(4-chloro-3-(trifluoromethyl)phenoxy)-3,5-difluorophenyl)ethan-1-ol
CAS No.:1380429-50-4
Molecular Formula:C₁₅H₁₀ClF₅O₂
Molecular Weight:352.688
Hs Code.:

Synonyms:2-(4-(4-chloro-3-(trifluoromethyl)phenoxy)-3,5-difluorophenyl)ethan-1-ol

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Chemical Property of 2-(4-(4-chloro-3-(trifluoromethyl)phenoxy)-3,5-difluorophenyl)ethan-1-ol

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Technology Process of 2-(4-(4-chloro-3-(trifluoromethyl)phenoxy)-3,5-difluorophenyl)ethan-1-ol

There total 4 articles about 2-(4-(4-chloro-3-(trifluoromethyl)phenoxy)-3,5-difluorophenyl)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1380429-49-1
4-chloro-3-(trifluoromethyl)phenyl-4-ethenyl-2,6-difluorophenyl ether

: 1380429-50-4
2-(4-(4-chloro-3-(trifluoromethyl)phenoxy)-3,5-difluorophenyl)ethan-1-ol

Guidance literature:: 4-chloro-3-(trifluoromethyl)phenyl-4-ethenyl-2,6-difluorophenyl ether; With 9-borabicyclo[3.3.1]nonane; In tetrahydrofuran; at 0 - 20 ℃;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; at 55 ℃; for 4h;

Reference yield:

: 1380429-48-0
4-(4-chloro-3-(trifluoromethyl)phenoxy)-3,5-difluorobenzaldehyde

: 1380429-50-4
2-(4-(4-chloro-3-(trifluoromethyl)phenoxy)-3,5-difluorophenyl)ethan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 2 h / 20 °C

2.1: borane-THF / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere; Cooling with ice

2.2: 2 h / 60 °C / Cooling with ice

With sodium tetrahydroborate; borane-THF; In tetrahydrofuran;

Reference yield:

: 6294-93-5
4-chloro-3-trifluoromethylphenol

: 1380429-50-4
2-(4-(4-chloro-3-(trifluoromethyl)phenoxy)-3,5-difluorophenyl)ethan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 120 °C / Inert atmosphere

2.1: sodium tetrahydroborate / tetrahydrofuran / 2 h / 20 °C

3.1: borane-THF / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere; Cooling with ice

3.2: 2 h / 60 °C / Cooling with ice

With sodium tetrahydroborate; borane-THF; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;