{(S)-1-[({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

Base Information

Chemical Name:{(S)-1-[({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester
CAS No.:59179-92-9
Molecular Formula:C₃₃H₂₉Cl₂N₃O₅
Molecular Weight:618.516
Hs Code.:

Synonyms:{(S)-1-[({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

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Chemical Property of {(S)-1-[({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

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Technology Process of {(S)-1-[({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

There total 7 articles about {(S)-1-[({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 59179-99-6
5-chloro-3-(o-chlorophenyl)-1-methyl-2-<α-<(benzyloxycarbonyl)phenylalanyl>amino>methyl>indole

: 59179-92-9
{(S)-1-[({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

Guidance literature:: With chromium(VI) oxide; In water; acetic acid; Ambient temperature;
DOI:10.1021/jm00181a013

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 59179-92-9
{(S)-1-[({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90.7 percent / DCC, N-hydroxysuccinimide / dimethylformamide / a) -20 deg C, 2 h, b) RT, 2 h

2: 57 percent / CrO₃ / acetic acid; H₂O / Ambient temperature

With chromium(VI) oxide; 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00181a013

Reference yield:

: 24107-07-1
ethyl 5-chloro-3-(o-chlorophenyl)-indole-2-carboxylate

: 59179-92-9
{(S)-1-[({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMF, RT, 1.5 h, 2.) DMF, RT, overnight

2: 98.5 percent / 86percent KOH / ethanol / 2 h / Heating

3: 1.) SOCl₂, 2.) NH₃ (gas) / 1.) reflux, 3 h, 2.) THF, RT, 3 h

4: LiAlH₄ / diethyl ether / a) RT, 10.5 h, b) reflux, 4 h

5: 90.7 percent / DCC, N-hydroxysuccinimide / dimethylformamide / a) -20 deg C, 2 h, b) RT, 2 h

6: 57 percent / CrO₃ / acetic acid; H₂O / Ambient temperature

With chromium(VI) oxide; potassium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; lithium aluminium tetrahydride; thionyl chloride; ammonia; sodium hydride; dicyclohexyl-carbodiimide; In diethyl ether; ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00181a013