PYRIMIDIN-2-YLBORONIC ACID

Base Information

• Chemical Name: PYRIMIDIN-2-YLBORONIC ACID
• CAS No.: 851199-85-4
• Molecular Formula: C4H5BN2O2
• Molecular Weight: 123.907
• Mol file: 851199-85-4.mol

Synonyms:Pyrimidine-2-boronic acid;

Chemical Property of PYRIMIDIN-2-YLBORONIC ACID

Chemical Property:

• Boiling Point: 371.416 °C at 760 mmHg
• Flash Point: 178.426 °C
• PSA: 66.24000
• Density: 1.335 g/cm³
• LogP: -1.84360

Purity/Quality:

98%min ^*data from raw suppliers

PYRIMIDIN-2-YLBORONIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Pyrimidine-2-boronic Acid is a compound useful in organic synthesis, and for studies on organoboron compounds.

Technology Process of PYRIMIDIN-2-YLBORONIC ACID

There total 2 articles about PYRIMIDIN-2-YLBORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Trimethyl borate (121-43-7,63156-11-6) + water (7732-18-5) + 2-bromopyrimidine (4595-60-2) → (pyrimidin-2-yl)boronic acid (851199-85-4)

Guidance literature:

2-bromopyrimidine; With n-butyllithium; In diethyl ether; at -78 ℃; for 1h; Inert atmosphere;

Trimethyl borate; In diethyl ether; at -78 ℃; for 0.5h; Inert atmosphere;

water; With hydrogenchloride; In diethyl ether; at 20 ℃; for 12h; Inert atmosphere;

Reference yield:

→ (pyrimidin-2-yl)boronic acid (851199-85-4)

Guidance literature:

With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.5h;

In diethyl ether; hexane; at -78 - 20 ℃;

Reference yield: 85.0%

(pyrimidin-2-yl)boronic acid (851199-85-4) + 6,6′-dibromo-9,9′-diphenyl-9H,9′H-3,3′-bicarbazole (354135-75-4) → 3,3'-bis(2,4-pyrimidinyl)-6,6'-bis(9-phenylcarbazole)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; at 110 ℃; for 24h; Inert atmosphere;

upstream raw materials:

Trimethyl borate

water

2-bromopyrimidine

Downstream raw materials:

N-(3-((dimethylamino)methyl)phenyl)-4-(pyrimidin-2-yl)benzenesulfonamide

2-(4-bromophenyl)pyrimidine

4-methoxycarbonyl aniline

Refernces

• 1、 -. "COMPOUND FOR ORGANIC ELECTRONIC ELEMENT, ORGANIC ELECTRONIC ELEMENT USING THE SAME, AND AN ELECTRONIC DEVICE THEREOF". Paragraph 0157; 0166; 0167. . Retrieved 2016/10/07.