dimethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)isophthalate

Base Information

• Chemical Name: dimethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)isophthalate
• CAS No.: 1312919-77-9
• Molecular Formula: C₂₈H₂₁FN₂O₇S
• Molecular Weight: 548.548
• Mol file: 1312919-77-9.mol

Synonyms:dimethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)isophthalate

Chemical Property of dimethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)isophthalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)isophthalate

There total 6 articles about dimethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)isophthalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

C18H11ClFNO3S (1092117-57-1) + dimethyl 4-aminoisophthalate (63746-12-3) → dimethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)isophthalate (1312919-77-9)

Guidance literature:

With pyridine; triethylamine; In dichloromethane; at 50 ℃; for 48h; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.04.011

Reference yield:

5-carboxy-N-benzylanthranilic acid (1002965-95-8) → dimethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)isophthalate (1312919-77-9)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 48 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 20 °C

3: pyridine; triethylamine / dichloromethane / 48 h / 50 °C / Inert atmosphere

With pyridine; thionyl chloride; palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane;

DOI:10.1016/j.ejmech.2011.04.011

Reference yield:

4-bromo-isophthalic acid (6939-93-1) → dimethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)isophthalate (1312919-77-9)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(I) oxide; copper; potassium carbonate / 2-ethoxy-ethanol / 0.75 h / 130 °C / Microwave irradiation; Inert atmosphere

2: thionyl chloride / 48 h / 20 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 20 °C

4: pyridine; triethylamine / dichloromethane / 48 h / 50 °C / Inert atmosphere

With pyridine; copper(I) oxide; thionyl chloride; palladium 10% on activated carbon; hydrogen; copper; potassium carbonate; triethylamine; In methanol; 2-ethoxy-ethanol; dichloromethane;

DOI:10.1016/j.ejmech.2011.04.011

upstream raw materials:

5-carboxy-N-benzylanthranilic acid

C₁₈H₁₁ClFNO₃S

dimethyl 4-aminoisophthalate

dimethyl 4-(benzylamino)isophthalate

Downstream raw materials:

4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)isophthalic acid