4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)isophthalic acid

Base Information

Chemical Name:4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)isophthalic acid
CAS No.:1312919-95-1
Molecular Formula:C₂₆H₁₇FN₂O₇S
Molecular Weight:520.495
Hs Code.:

Synonyms:4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)isophthalic acid

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Chemical Property of 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)isophthalic acid

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Technology Process of 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)isophthalic acid

There total 8 articles about 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)isophthalic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1312919-77-9
dimethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)isophthalate

: 1312919-95-1
4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)isophthalic acid

Guidance literature:: dimethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)isophthalate; With lithium hydroxide; In 1,4-dioxane; at 20 ℃; Inert atmosphere;

With hydrogenchloride; In water; pH=2; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.04.011

Reference yield:

: 1312919-57-5
dimethyl 4-(benzylamino)isophthalate

: 1312919-95-1
4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)isophthalic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 20 °C

2.1: pyridine; triethylamine / dichloromethane / 48 h / 50 °C / Inert atmosphere

3.1: lithium hydroxide / 1,4-dioxane / 20 °C / Inert atmosphere

3.2: pH 2 / Inert atmosphere

With pyridine; palladium 10% on activated carbon; hydrogen; triethylamine; lithium hydroxide; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.04.011

Reference yield:

: 1002965-95-8
5-carboxy-N-benzylanthranilic acid

: 1312919-95-1
4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)isophthalic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 48 h / 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 20 °C

3.1: pyridine; triethylamine / dichloromethane / 48 h / 50 °C / Inert atmosphere

4.1: lithium hydroxide / 1,4-dioxane / 20 °C / Inert atmosphere

4.2: pH 2 / Inert atmosphere

With pyridine; thionyl chloride; palladium 10% on activated carbon; hydrogen; triethylamine; lithium hydroxide; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.04.011