(3S,7S,9S)-7,9-dimethyl-2-{N-[(methyloxy)carbonyl]-L-valyl}-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxylic acid

Base Information

Chemical Name:(3S,7S,9S)-7,9-dimethyl-2-{N-[(methyloxy)carbonyl]-L-valyl}-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxylic acid
CAS No.:1272654-75-7
Molecular Formula:C₁₇H₂₈N₂O₇
Molecular Weight:372.419
Hs Code.:

Synonyms:(3S,7S,9S)-7,9-dimethyl-2-{N-[(methyloxy)carbonyl]-L-valyl}-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxylic acid

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Chemical Property of (3S,7S,9S)-7,9-dimethyl-2-{N-[(methyloxy)carbonyl]-L-valyl}-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxylic acid

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Technology Process of (3S,7S,9S)-7,9-dimethyl-2-{N-[(methyloxy)carbonyl]-L-valyl}-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxylic acid

There total 1 articles about (3S,7S,9S)-7,9-dimethyl-2-{N-[(methyloxy)carbonyl]-L-valyl}-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 1272654-75-7
(3S,7S,9S)-7,9-dimethyl-2-{N-[(methyloxy)carbonyl]-L-valyl}-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: HATU; triethylamine

2: Dess-Martin periodane

3: toluene-4-sulfonic acid

4: water; lithium hydroxide / tetrahydrofuran; tert-butyl alcohol / 2 h / 20 °C

With water; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine; HATU; lithium hydroxide; In tetrahydrofuran; tert-butyl alcohol;

Reference yield: 61.0%

: 1272654-75-7
(3S,7S,9S)-7,9-dimethyl-2-{N-[(methyloxy)carbonyl]-L-valyl}-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxylic acid

: methyl{(1S)-1-[((2S)-2-{4-[4'-(aminoacetyl)-4-biphenylyl]-1H-imidazol-2-yl}-1-pyrrolidinyl)carbonyl]-2-methylpropyl}carbamate dihydrochloride

: 1272655-00-1
C₄₅H₅₉N₇O₁₀

Guidance literature:: (3S,7S,9S)-7,9-dimethyl-2-{N-[(methyloxy)carbonyl]-L-valyl}-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxylic acid; With triethylamine; HATU; In N,N-dimethyl-formamide; for 0.05h;

methyl{(1S)-1-[((2S)-2-{4-[4'-(aminoacetyl)-4-biphenylyl]-1H-imidazol-2-yl}-1-pyrrolidinyl)carbonyl]-2-methylpropyl}carbamate dihydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield: 61.0%

: 1272654-75-7
(3S,7S,9S)-7,9-dimethyl-2-{N-[(methyloxy)carbonyl]-L-valyl}-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxylic acid

: methyl {(1S)-1-[((2S)-2-{4-4'-(aminoacetyl)-[4-biphenylyl]-1H-imidazol-2-yl}-1-pyrrolidinyl)carbonyl]-2-methylpropyl}carbamate dihydrochloride

: 1272655-00-1
C₄₅H₅₉N₇O₁₀

Guidance literature:: (3S,7S,9S)-7,9-dimethyl-2-{N-[(methyloxy)carbonyl]-L-valyl}-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxylic acid; With triethylamine; HATU; In N,N-dimethyl-formamide; for 0.05h; Inert atmosphere;

methyl {(1S)-1-[((2S)-2-{4-4'-(aminoacetyl)-[4-biphenylyl]-1H-imidazol-2-yl}-1-pyrrolidinyl)carbonyl]-2-methylpropyl}carbamate dihydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;