(S)-2-Chloro-decanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Base Information

Chemical Name:(S)-2-Chloro-decanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester
CAS No.:104898-00-2
Molecular Formula:C₃₂H₅₆ClNO₄S
Molecular Weight:586.32
Hs Code.:

Synonyms:(S)-2-Chloro-decanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

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Chemical Property of (S)-2-Chloro-decanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

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Technology Process of (S)-2-Chloro-decanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

There total 29 articles about (S)-2-Chloro-decanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 104897-93-0
N,N-Dicyclohexyl-C-[(1S,2R,4R)-7,7-dimethyl-2-((E)-1-trimethylsilanyloxy-dec-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide

: 104898-00-2
(S)-2-Chloro-decanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: With N-chloro-succinimide; In tetrahydrofuran; 1.) -78 to 0 deg C, 3 h 2.) 0 deg C, 30 min. d.e. 99 percent;

Reference yield:

: 104897-89-4
N,N-Dicyclohexyl-C-[(1S,2R,4R)-7,7-dimethyl-2-((E)-1-trimethylsilanyloxy-hex-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide

: 104898-00-2
2-Chloro-decanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 67 percent / N-Chloro-succinimide / tetrahydrofuran / 1.) -78 deg C, 3 h 2.) 0 deg C, 30 min. d.e. 96 percent

2: 90 percent / Ca(BH₄)2 / tetrahydrofuran

3: AgCN

4: 1.) n-BuLi, diisopropylamine / 1.) THF, hexane, - 78 deg C 2.) -78 deg C, 1 h.

5: 62 percent / N-Chloro-succinimide / tetrahydrofuran / 1.) -78 to 0 deg C, 3 h 2.) 0 deg C, 30 min. d.e. 99 percent

6: LiCl

With N-chloro-succinimide; n-butyllithium; calcium borohydride; silver cyanide; diisopropylamine; lithium chloride; In tetrahydrofuran;

Reference yield:

: 104897-89-4
N,N-Dicyclohexyl-C-[(1S,2R,4R)-7,7-dimethyl-2-((E)-1-trimethylsilanyloxy-hex-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide

: 104898-00-2
(S)-2-Chloro-decanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / N-Chloro-succinimide / tetrahydrofuran / 1.) -78 deg C, 3 h 2.) 0 deg C, 30 min. d.e. 96 percent

2: 90 percent / Ca(BH₄)2 / tetrahydrofuran

3: AgCN

4: 1.) n-BuLi, diisopropylamine / 1.) THF, hexane, - 78 deg C 2.) -78 deg C, 1 h.

5: 62 percent / N-Chloro-succinimide / tetrahydrofuran / 1.) -78 to 0 deg C, 3 h 2.) 0 deg C, 30 min. d.e. 99 percent

With N-chloro-succinimide; n-butyllithium; calcium borohydride; silver cyanide; diisopropylamine; In tetrahydrofuran;