N,N-Dicyclohexyl-C-[(1S,2R,4R)-7,7-dimethyl-2-((Z)-4-methyl-1-trimethylsilanyloxy-pent-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide

Base Information

Chemical Name:N,N-Dicyclohexyl-C-[(1S,2R,4R)-7,7-dimethyl-2-((Z)-4-methyl-1-trimethylsilanyloxy-pent-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide
CAS No.:104897-91-8
Molecular Formula:C₃₁H₅₇NO₄SSi
Molecular Weight:567.949
Hs Code.:

Synonyms:N,N-Dicyclohexyl-C-[(1S,2R,4R)-7,7-dimethyl-2-((Z)-4-methyl-1-trimethylsilanyloxy-pent-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide

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Chemical Property of N,N-Dicyclohexyl-C-[(1S,2R,4R)-7,7-dimethyl-2-((Z)-4-methyl-1-trimethylsilanyloxy-pent-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide

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Technology Process of N,N-Dicyclohexyl-C-[(1S,2R,4R)-7,7-dimethyl-2-((Z)-4-methyl-1-trimethylsilanyloxy-pent-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide

There total 15 articles about N,N-Dicyclohexyl-C-[(1S,2R,4R)-7,7-dimethyl-2-((Z)-4-methyl-1-trimethylsilanyloxy-pent-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96864-31-2
<(1S,2R)-10-(N,N-dicyclohexylaminosulfonyl)born-2-yl>propionate

: 104897-91-8
N,N-Dicyclohexyl-C-[(1S,2R,4R)-7,7-dimethyl-2-((Z)-4-methyl-1-trimethylsilanyloxy-pent-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / lithium diisopropylamide / tetrahydrofuran / from -78 degC to r.t. over 3 h

2: 81 percent / Ti-(O-i-Pr)4, TiCl₄ / CH₂Cl₂ / 1 h / -78 °C

3: 1.) CF₃COOH; 2.) H₂ / 2.) PtO₂ / 1.) CH₂Cl₂, 0 degC, 5 min then r.t., 3 h; 2.)EtOH, 75 psi, r.t.

4: 94 percent / ethanol / 60 h / Ambient temperature

5: 84 percent / AgCN / toluene / 5 h / 90 °C

6: LiN(i-Pr)2 / tetrahydrofuran / -78 °C

With titanium(IV) isopropylate; silver cyanide; hydrogen; titanium tetrachloride; trifluoroacetic acid; lithium diisopropyl amide; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)86059-2

Reference yield:

: 110449-37-1
<(1S,2R)-10-(N,N-dicyclohexylaminosulfonyl)born-2-yl> <(2S)-2-(N,N'-di-tert-butoxycarbonyl)>hydrazinopropionate

: 104897-91-8
N,N-Dicyclohexyl-C-[(1S,2R,4R)-7,7-dimethyl-2-((Z)-4-methyl-1-trimethylsilanyloxy-pent-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) CF₃COOH; 2.) H₂ / 2.) PtO₂ / 1.) CH₂Cl₂, 0 degC, 5 min then r.t., 3 h; 2.)EtOH, 75 psi, r.t.

2: 94 percent / ethanol / 60 h / Ambient temperature

3: 84 percent / AgCN / toluene / 5 h / 90 °C

4: LiN(i-Pr)2 / tetrahydrofuran / -78 °C

With silver cyanide; hydrogen; trifluoroacetic acid; lithium diisopropyl amide; platinum(IV) oxide; In tetrahydrofuran; ethanol; toluene;
DOI:10.1016/S0040-4020(01)86059-2

Reference yield:

: 104897-88-3,125091-73-8
N,N-Dicyclohexyl-C-[(1S,2R,4R)-7,7-dimethyl-2-((Z)-1-trimethylsilanyloxy-propenyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide

: 104897-91-8
N,N-Dicyclohexyl-C-[(1S,2R,4R)-7,7-dimethyl-2-((Z)-4-methyl-1-trimethylsilanyloxy-pent-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 81 percent / Ti-(O-i-Pr)4, TiCl₄ / CH₂Cl₂ / 1 h / -78 °C

2: 1.) CF₃COOH; 2.) H₂ / 2.) PtO₂ / 1.) CH₂Cl₂, 0 degC, 5 min then r.t., 3 h; 2.)EtOH, 75 psi, r.t.

3: 94 percent / ethanol / 60 h / Ambient temperature

4: 84 percent / AgCN / toluene / 5 h / 90 °C

5: LiN(i-Pr)2 / tetrahydrofuran / -78 °C

With titanium(IV) isopropylate; silver cyanide; hydrogen; titanium tetrachloride; trifluoroacetic acid; lithium diisopropyl amide; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)86059-2