Technology Process of meptazinol 6-aminonicotinic acid carbamate
There total 4 articles about meptazinol 6-aminonicotinic acid carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 3h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylamine / N,N-dimethyl-formamide / 19 h / 55 - 57 °C
2: triethylamine / dichloromethane; toluene; tetrahydrofuran / 0.5 h / -76 - -67 °C / Inert atmosphere
3: dichloromethane; toluene; tetrahydrofuran / 1.5 h / -76 - 20 °C / Inert atmosphere
4: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
With
hydrogen; triethylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
2: Schotten-Baumann Reaction;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: dichloromethane; toluene; tetrahydrofuran / 1.5 h / -76 - 20 °C / Inert atmosphere
2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
With
hydrogen;
palladium 10% on activated carbon;
In
tetrahydrofuran; dichloromethane; toluene;
