1,3,4,6-tetra-O-acetyl-2-deoxy-2-[(fluoroacetyl)amino]-beta-D-glucopyranose

Base Information

• Chemical Name: 1,3,4,6-tetra-O-acetyl-2-deoxy-2-[(fluoroacetyl)amino]-beta-D-glucopyranose
• CAS No.: 35237-61-7
• Molecular Formula: C₁₆H₂₂FNO₁₀
• Molecular Weight: 407.35
• Mol file: 35237-61-7.mol

Synonyms:1,3,4,6-Tetra-O-Acetyl-N-fluoroacetyl-b-D-glucosamine

Chemical Property of 1,3,4,6-tetra-O-acetyl-2-deoxy-2-[(fluoroacetyl)amino]-beta-D-glucopyranose

Chemical Property:

• Vapor Pressure: 1.3E-11mmHg at 25°C
• Boiling Point: 537.2°Cat760mmHg
• PKA: 11.00±0.70(Predicted)
• Flash Point: 278.7°C
• PSA: 143.53000
• Density: 1.33g/cm³
• LogP: -0.45390

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3,4,6-tetra-O-acetyl-2-deoxy-2-[(fluoroacetyl)amino]-beta-D-glucopyranose

There total 3 articles about 1,3,4,6-tetra-O-acetyl-2-deoxy-2-[(fluoroacetyl)amino]-beta-D-glucopyranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

Fluoroacetic acid (144-49-0) + 1,3,4,6-tetra-O-acetyl-D-glucosamine hydrochloride (5432-46-2,10034-19-2,10034-20-5,34948-62-4,110253-00-4,1191127-63-5) → 1,3,4,6-Tetra-O-acetyl-2-desoxy-2-fluoracetamido-β-D-glucose (35237-61-7)

Guidance literature:

1,3,4,6-tetra-O-acetyl-D-glucosamine hydrochloride; With pyridine; triethylamine; In N,N-dimethyl-formamide; at 0 ℃;

Fluoroacetic acid; With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 ℃; for 16h;

DOI:10.1021/ja904506u

Reference yield:

1,3,4,6-tetra-O-acetyl-D-glucosamine hydrochloride (5432-46-2,10034-19-2,10034-20-5,34948-62-4,110253-00-4,1191127-63-5) + sodium fluoroacetate (62-74-8) → 1,3,4,6-Tetra-O-acetyl-2-desoxy-2-fluoracetamido-β-D-glucose (35237-61-7)

Guidance literature:

With pyridine; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 ℃; for 17h;

Reference yield:

→ 1,3,4,6-Tetra-O-acetyl-2-desoxy-2-fluoracetamido-β-D-glucose (35237-61-7)

Guidance literature:

laut Lit.;

DOI:10.1021/jm00210a010

upstream raw materials:

1,3,4,6-tetra-O-acetyl-D-glucosamine hydrochloride

sodium fluoroacetate

Fluoroacetic acid