Sodium fluoroacetate

Base Information Edit

Chemical Name:Sodium fluoroacetate
CAS No.:62-74-8
Deprecated CAS:1081840-06-3
Molecular Formula:C2H3 F O2 . Na
Molecular Weight:100.025
Hs Code.:29159000
European Community (EC) Number:200-548-2
UNII:166WTM3843
UN Number:2629,2629 (Sodium fluoroacetate)
ChEMBL ID:CHEMBL369611
DSSTox Substance ID:DTXSID8024311
ICSC Number:0484
NCI Thesaurus Code:C163700
Nikkaji Number:J2.353A
Wikidata:Q410911
Wikipedia:Sodium_fluoroacetate
Mol file:62-74-8.mol

Synonyms:Compound 1080;fluoroacetic acid;fluoroacetic acid, 18F-labeled;fluoroacetic acid, aluminum salt;fluoroacetic acid, ammonium salt;fluoroacetic acid, ammonium salt, 2-(14)C-labeled;fluoroacetic acid, barium salt;fluoroacetic acid, cadmium salt;fluoroacetic acid, calcium salt;fluoroacetic acid, copper (2+) salt;fluoroacetic acid, lead (+4) salt;fluoroacetic acid, magnesium salt;fluoroacetic acid, mercury (2+) salt;fluoroacetic acid, potassium salt;fluoroacetic acid, sodium salt;fluoroacetic acid, terbium (+3) salt;monofluoroacetate;monofluoroacetic acid;sodium (18F)fluoroacetate;sodium fluoroacetate

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Chemical Property of Sodium fluoroacetate Edit

Chemical Property:

Appearance/Colour:white odourless hygroscopic powder
Vapor Pressure:0.828mmHg at 25°C
Melting Point:200-205 °C (dec.)
Boiling Point:167.9°C at 760 mmHg
PKA:2.66
Flash Point:55.3°C
PSA：40.13000
LogP:-1.29420
Water Solubility.:Very soluble
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:99.99365175
Heavy Atom Count:6
Complexity:46.8
Transport DOT Label:Poison

Purity/Quality:

Safty Information:

Pictogram(s): Toxic by ingestion, inhalation, and skin absorption. TLV: 0.05 mg/m³; STEL 0.15 mg/m³. Toxic by skin absorption. For use by trained operators only, use has been restricted.
Hazard Codes:T+,N,T
Statements: 26/27/28-50
Safety Statements: 13-22-36/37-45-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C(C(=O)[O-])F.[Na+]
Inhalation Risk:Evaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly.
Effects of Short Term Exposure:The substance may cause effects on the cardiovascular system and central nervous system. This may result in cardiac disorders and respiratory failure. Exposure could cause death.
Description Sodium fluoroacetate is the salt of a naturally occurring toxin which is found in Australia, Brazil, and Africa. Naturally occurring fluoroacetate can be found in Gastrolobium minus (family: Fabaceae), a flowering plant in Western Australia and often referred to as the ‘poison pea.’ Descriptions of the fluoroacetate activity may have been described as early at 1904 in Sierra Leone, when colonists used extracts of Chailletia toxicaria to poison rats. The actions of fluoroacetate have also been described in animals having ingested the poison leaf Gifblaar (Dichapetalum cymosum). Sodium fluoroacetate was then developed as a rodenticide and predacide in 1942 in the United States and went under the synonym of 1080, which is its catalog number. In the late 1970s, the use of sodium fluoroacetate was significantly restricted in the United States due to its high acute toxicity and the need for specialized training for application. Additional restrictions were also imposed as to the locations that the agent could be used and under very defined conditions. A ‘toxic collar’ was developed which contains a very small amount of sodium fluoroacetate (0.3 mg per collar). This collar could be placed around the throats of livestock and would contain chemical pouches that would be ruptured when the animal was attacked by a predator thus restricting the poison only to the predator. The toxicity in certain predators (dogs, wolves, coyotes) is up to 20-fold higher than in humans. Amphibians and other reptiles have been shown to be relatively resistant to sodium fluoroacetate and can feed on insects and other animals which have high levels of sodium fluoroacetate present with no ill-effects. In the late 1980s, all use of sodium fluoroacetate as a rodenticide was discontinued. The availability of products containing sodium fluoroacetate is permitted by the Environmental Protection Agency (EPA) and the regulatory conclusion of the EPA is that these products will not pose unreasonable risks or adverse effects if the products are used following the restriction on the product labeling.
Uses Predator elimination (coyotes), rodenticide. Sodium fluoroacetate is used for rodent control in restricted environments and for the control of the brushtail possum and other wild mammals in some countries. Rodenticide (restricted use)

Technology Process of Sodium fluoroacetate

There total 4 articles about Sodium fluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%