8-Acetoxymethyl-4-benzyloxy-7,8-dihydro-3H-pyrrolo[3,2-e]indole-1,2,6-tricarboxylic acid 6-tert-butyl ester 1,2-dimethyl ester

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Chemical Name:8-Acetoxymethyl-4-benzyloxy-7,8-dihydro-3H-pyrrolo[3,2-e]indole-1,2,6-tricarboxylic acid 6-tert-butyl ester 1,2-dimethyl ester
CAS No.:156905-81-6
Molecular Formula:C₂₉H₃₂N₂O₉
Molecular Weight:552.581
Hs Code.:

Synonyms:8-Acetoxymethyl-4-benzyloxy-7,8-dihydro-3H-pyrrolo[3,2-e]indole-1,2,6-tricarboxylic acid 6-tert-butyl ester 1,2-dimethyl ester

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Chemical Property of 8-Acetoxymethyl-4-benzyloxy-7,8-dihydro-3H-pyrrolo[3,2-e]indole-1,2,6-tricarboxylic acid 6-tert-butyl ester 1,2-dimethyl ester

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Technology Process of 8-Acetoxymethyl-4-benzyloxy-7,8-dihydro-3H-pyrrolo[3,2-e]indole-1,2,6-tricarboxylic acid 6-tert-butyl ester 1,2-dimethyl ester

There total 3 articles about 8-Acetoxymethyl-4-benzyloxy-7,8-dihydro-3H-pyrrolo[3,2-e]indole-1,2,6-tricarboxylic acid 6-tert-butyl ester 1,2-dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: (E)-2-(3-Acetoxymethyl-6-benzyloxy-1-tert-butoxycarbonyl-2,3-dihydro-1H-indol-5-ylamino)-but-2-enedioic acid dimethyl ester

: 156905-81-6
8-Acetoxymethyl-4-benzyloxy-7,8-dihydro-3H-pyrrolo[3,2-e]indole-1,2,6-tricarboxylic acid 6-tert-butyl ester 1,2-dimethyl ester

Guidance literature:: With palladium diacetate; In N,N-dimethyl acetamide; at 70 ℃; for 3.5h;
DOI:10.1016/S0960-894X(97)00099-1

Reference yield:

: 132628-60-5
3-acetoxymethyl-5-amino-6-benzyloxy-1-t-butoxycarbonyl-2,3-dihydro-1H-indole

: 156905-81-6
8-Acetoxymethyl-4-benzyloxy-7,8-dihydro-3H-pyrrolo[3,2-e]indole-1,2,6-tricarboxylic acid 6-tert-butyl ester 1,2-dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / methanol / 1 h / 0 - 20 °C

2: 49 percent / Pd(OAc)2 / N,N-dimethyl-acetamide / 3.5 h / 70 °C

With palladium diacetate; In methanol; N,N-dimethyl acetamide;
DOI:10.1016/S0960-894X(97)00099-1

Reference yield:

: 762-42-5
dimethyl acetylenedicarboxylate

: 156905-81-6
8-Acetoxymethyl-4-benzyloxy-7,8-dihydro-3H-pyrrolo[3,2-e]indole-1,2,6-tricarboxylic acid 6-tert-butyl ester 1,2-dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / methanol / 1 h / 0 - 20 °C

2: 49 percent / Pd(OAc)2 / N,N-dimethyl-acetamide / 3.5 h / 70 °C

With palladium diacetate; In methanol; N,N-dimethyl acetamide;
DOI:10.1016/S0960-894X(97)00099-1