Technology Process of (E)-3-(benzo[d][1,3]dioxol-5-yl)allyl 3-(3,4,5-trimethoxyphenyl)propiolate
There total 5 articles about (E)-3-(benzo[d][1,3]dioxol-5-yl)allyl 3-(3,4,5-trimethoxyphenyl)propiolate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dicyclohexyl-carbodiimide;
In
pyridine;
for 1h;
Ambient temperature;
DOI:10.1248/cpb.39.192
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triphenylphosphine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere
2.2: 20 h / 20 °C / Inert atmosphere
3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48 h / 0 - 20 °C / Inert atmosphere
With
n-butyllithium; di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran; dichloromethane;
2.1: |Corey-Fuchs Alkyne Synthesis;
DOI:10.1021/acs.joc.7b02957
- Guidance literature:
-
Multi-step reaction with 2 steps
1: diisobutylaluminium hydride / dichloromethane; n-heptane / 2 h / 0 - 20 °C / Inert atmosphere
2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48 h / 0 - 20 °C / Inert atmosphere
With
di-isopropyl azodicarboxylate; diisobutylaluminium hydride; triphenylphosphine;
In
tetrahydrofuran; n-heptane; dichloromethane;
DOI:10.1021/acs.joc.7b02957
