{[4-(2-{4-[2-(4-ethynyl-2,5-dimethoxyphenyl)ethynyl]phenyl}ethynyl)phenyl]methoxy}triisopropylsilane

Base Information

• Chemical Name: {[4-(2-{4-[2-(4-ethynyl-2,5-dimethoxyphenyl)ethynyl]phenyl}ethynyl)phenyl]methoxy}triisopropylsilane
• CAS No.: 1429466-21-6
• Molecular Formula: C₃₆H₄₀O₃Si
• Molecular Weight: 548.797
• Mol file: 1429466-21-6.mol

Synonyms:{[4-(2-{4-[2-(4-ethynyl-2,5-dimethoxyphenyl)ethynyl]phenyl}ethynyl)phenyl]methoxy}triisopropylsilane

Chemical Property of {[4-(2-{4-[2-(4-ethynyl-2,5-dimethoxyphenyl)ethynyl]phenyl}ethynyl)phenyl]methoxy}triisopropylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {[4-(2-{4-[2-(4-ethynyl-2,5-dimethoxyphenyl)ethynyl]phenyl}ethynyl)phenyl]methoxy}triisopropylsilane

There total 6 articles about {[4-(2-{4-[2-(4-ethynyl-2,5-dimethoxyphenyl)ethynyl]phenyl}ethynyl)phenyl]methoxy}triisopropylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-{2,5-dimethoxy-4-[2-(4-{2-[4-({[tris(propan-2-yl)silyl]oxy}methyl)phenyl]ethynyl}phenyl)ethynyl]phenyl}-2-methylbut-3-yn-2-ol (1429466-20-5) → {[4-(2-{4-[2-(4-ethynyl-2,5-dimethoxyphenyl)ethynyl]phenyl}ethynyl)phenyl]methoxy}triisopropylsilane (1429466-21-6)

Guidance literature:

With sodium hydroxide; In toluene; at 115 ℃; for 1.33333h; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.02.105

Reference yield:

(4-ethynylphenyl)methanol (10602-04-7) → {[4-(2-{4-[2-(4-ethynyl-2,5-dimethoxyphenyl)ethynyl]phenyl}ethynyl)phenyl]methoxy}triisopropylsilane (1429466-21-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 1H-imidazole / dichloromethane

2: triethylamine; bis(triphenylphosphine)palladium(II) dichloride; copper(l) iodide / tetrahydrofuran

3: sodium hydroxide / toluene

4: triethylamine; bis(triphenylphosphine)palladium(II) dichloride; copper(l) iodide / tetrahydrofuran / 0.13 h / 100 °C / Microwave irradiation

5: sodium hydroxide / toluene / 1.33 h / 115 °C / Inert atmosphere

With 1H-imidazole; copper(l) iodide; bis(triphenylphosphine)palladium(II) dichloride; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1016/j.tetlet.2013.02.105

Reference yield:

(4-ethynylbenzyloxy)triisopropylsilane (851227-22-0) → {[4-(2-{4-[2-(4-ethynyl-2,5-dimethoxyphenyl)ethynyl]phenyl}ethynyl)phenyl]methoxy}triisopropylsilane (1429466-21-6)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine; bis(triphenylphosphine)palladium(II) dichloride; copper(l) iodide / tetrahydrofuran

2: sodium hydroxide / toluene

3: triethylamine; bis(triphenylphosphine)palladium(II) dichloride; copper(l) iodide / tetrahydrofuran / 0.13 h / 100 °C / Microwave irradiation

4: sodium hydroxide / toluene / 1.33 h / 115 °C / Inert atmosphere

With copper(l) iodide; bis(triphenylphosphine)palladium(II) dichloride; triethylamine; sodium hydroxide; In tetrahydrofuran; toluene;

DOI:10.1016/j.tetlet.2013.02.105

upstream raw materials:

4-{2,5-dimethoxy-4-[2-(4-{2-[4-({[tris(propan-2-yl)silyl]oxy}methyl)phenyl]ethynyl}phenyl)ethynyl]phenyl}-2-methylbut-3-yn-2-ol

(4-ethynylphenyl)methanol

(4-ethynylbenzyloxy)triisopropylsilane

C₂₉H₃₈O₂Si

Downstream raw materials:

trans-(bis{[2,5-dimethoxy-4-(2-{4-[2-(4-{[(triisopropylsilyl)oxy]methyl}phenyl)ethynyl]-phenyl}ethynyl)phenyl]ethyne}bis(tri-n-butylphosphine))platinum