(R)-1-(3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

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Chemical Name:(R)-1-(3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one
CAS No.:1453853-65-0
Molecular Formula:C₂₉H₃₈ClFN₄O₃Si
Molecular Weight:573.183
Hs Code.:

Synonyms:(R)-1-(3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

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Chemical Property of (R)-1-(3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

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Technology Process of (R)-1-(3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

There total 11 articles about (R)-1-(3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.5%

: 1453851-67-6
(S)-3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propyl methanesulfonate

: 1453851-89-2
4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-pyridin-2(1H)-one

: 1453853-65-0
(R)-1-(3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: 4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-pyridin-2(1H)-one; With potassium hexamethylsilazane; In tetrahydrofuran; 2-methyltetrahydrofuran; at 0 ℃; for 0.25h;

(S)-3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propyl methanesulfonate; In tetrahydrofuran; 2-methyltetrahydrofuran; at 75 ℃;

Reference yield:

: 5527-95-7
4-chloro-3-fluorobenzaldehyde

: 1453853-65-0
(R)-1-(3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine / 17 h / 50 - 100 °C

2.1: chloro-trimethyl-silane / 20 h

3.1: diisobutylaluminium hydride / toluene / 4 h / -78 - 20 °C

4.1: D-(-)-diisopropyl tartrate; titanium(IV) isopropylate; tert.-butylhydroperoxide / dichloromethane; decane / 4.33 h / -20 °C / Molecular sieve

5.1: sodium bis(2-methoxyethoxy)aluminium dihydride / 1,2-dimethoxyethane / 3 h / 0 - 20 °C

6.1: 1H-imidazole / dichloromethane / 1 h / 0 °C

7.1: triethylamine / dichloromethane / 2 h / 0 °C

8.1: potassium hexamethylsilazane / tetrahydrofuran; 2-methyltetrahydrofuran / 0.25 h / 0 °C

8.2: 75 °C

With pyridine; 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; chloro-trimethyl-silane; potassium hexamethylsilazane; diisobutylaluminium hydride; D-(-)-diisopropyl tartrate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,2-dimethoxyethane; decane; dichloromethane; toluene;

Reference yield:

: 401815-98-3
2-fluoropyridin-4-ylboronic acid

: 1453853-65-0
(R)-1-(3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 3 h / 80 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; iso-butanol / 100 °C / Microwave irradiation; Sealed tube

3.1: hydrogenchloride / water / Reflux

4.1: potassium hexamethylsilazane / tetrahydrofuran; 2-methyltetrahydrofuran / 0.25 h / 0 °C

4.2: 75 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium hexamethylsilazane; sodium carbonate; N-ethyl-N,N-diisopropylamine; iso-butanol; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; water; 1.1: |Suzuki Coupling;