(S)-3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propyl methanesulfonate

Base Information

Chemical Name:(S)-3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propyl methanesulfonate
CAS No.:1453851-67-6
Molecular Formula:C₁₆H₂₆ClFO₄SSi
Molecular Weight:396.983
Hs Code.:

Synonyms:(S)-3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propyl methanesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propyl methanesulfonate

Chemical Property:

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Technology Process of (S)-3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propyl methanesulfonate

There total 7 articles about (S)-3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.1%

: 1453852-14-6
(S)-3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propan-1-ol

: methanesulfonic acid chloroanhydride

: 1453851-67-6
(S)-3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 2h;

Reference yield:

: 5527-95-7
4-chloro-3-fluorobenzaldehyde

: 1453851-67-6
(S)-3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propyl methanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / 17 h / 50 - 100 °C

2: chloro-trimethyl-silane / 20 h

3: diisobutylaluminium hydride / toluene / 4 h / -78 - 20 °C

4: D-(-)-diisopropyl tartrate; titanium(IV) isopropylate; tert.-butylhydroperoxide / dichloromethane; decane / 4.33 h / -20 °C / Molecular sieve

5: sodium bis(2-methoxyethoxy)aluminium dihydride / 1,2-dimethoxyethane / 3 h / 0 - 20 °C

6: 1H-imidazole / dichloromethane / 1 h / 0 °C

7: triethylamine / dichloromethane / 2 h / 0 °C

With pyridine; 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; chloro-trimethyl-silane; diisobutylaluminium hydride; D-(-)-diisopropyl tartrate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In 1,2-dimethoxyethane; decane; dichloromethane; toluene;

Reference yield:

: 1453852-08-8
(E)-3-(4-chloro-3-fluorophenyl)prop-2-en-1-ol

: 1453851-67-6
(S)-3-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)propyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: D-(-)-diisopropyl tartrate; titanium(IV) isopropylate; tert.-butylhydroperoxide / dichloromethane; decane / 4.33 h / -20 °C / Molecular sieve

2: sodium bis(2-methoxyethoxy)aluminium dihydride / 1,2-dimethoxyethane / 3 h / 0 - 20 °C

3: 1H-imidazole / dichloromethane / 1 h / 0 °C

4: triethylamine / dichloromethane / 2 h / 0 °C

With 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; D-(-)-diisopropyl tartrate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In 1,2-dimethoxyethane; decane; dichloromethane;