N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-[1-(2-cyano-ethoxy)-ethoxy]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-acetamide

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Chemical Name:N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-[1-(2-cyano-ethoxy)-ethoxy]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-acetamide
CAS No.:828247-72-9
Molecular Formula:C₃₈H₄₀N₆O₈
Molecular Weight:708.771
Hs Code.:

<i>N</i>-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-[1-(2-cyano-ethoxy)-ethoxy]-4-hydroxy-tetrahydro-furan-2-yl}-9<i>H</i>-purin-6-yl)-acetamide

Synonyms:N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-[1-(2-cyano-ethoxy)-ethoxy]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-acetamide

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Chemical Property of N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-[1-(2-cyano-ethoxy)-ethoxy]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-acetamide

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Technology Process of N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-[1-(2-cyano-ethoxy)-ethoxy]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-acetamide

There total 3 articles about N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-[1-(2-cyano-ethoxy)-ethoxy]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 828247-66-1
N-(9-{(2R,3R,3aR,9aR)-3-[1-(2-Cyano-ethoxy)-ethoxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-9H-purin-6-yl)-acetamide

: 828247-72-9
N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-[1-(2-cyano-ethoxy)-ethoxy]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-acetamide

Guidance literature:: N-(9-{(2R,3R,3aR,9aR)-3-[1-(2-Cyano-ethoxy)-ethoxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-9H-purin-6-yl)-acetamide; With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran;

4,4'-dimethoxytrityl chloride; In pyridine;
DOI:10.1016/j.tetlet.2004.10.151

Reference yield:

: 3386-87-6
1,2-bis-(2-cyanoethoxy)ethane

: 828247-72-9
N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-[1-(2-cyano-ethoxy)-ethoxy]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogen sulfate

2.1: 96 percent / p-toluenesulfonic acid / dioxane

3.1: tetrabutylammonium fluoride; acetic acid / tetrahydrofuran

3.2: 96 percent / pyridine

With sodium hydrogen sulfate; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/j.tetlet.2004.10.151

Reference yield:

: 828247-65-0
N⁶-acetyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenosine

: 828247-72-9
N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-[1-(2-cyano-ethoxy)-ethoxy]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 96 percent / p-toluenesulfonic acid / dioxane

2.1: tetrabutylammonium fluoride; acetic acid / tetrahydrofuran

2.2: 96 percent / pyridine

With tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/j.tetlet.2004.10.151