2-(4-((1-benzyl-2-(methylthio)-2-[⁽¹⁴⁾C]-imidazol-5-yl)methyl)-piperazin-1-yl)-N-isopropylpyridin-3-amine

Base Information

• Chemical Name: 2-(4-((1-benzyl-2-(methylthio)-2-[⁽¹⁴⁾C]-imidazol-5-yl)methyl)-piperazin-1-yl)-N-isopropylpyridin-3-amine
• CAS No.: 1316754-32-1
• Molecular Formula: C₂₄H₃₂N₆S
• Molecular Weight: 438.613

Synonyms:2-(4-((1-benzyl-2-(methylthio)-2-[⁽¹⁴⁾C]-imidazol-5-yl)methyl)-piperazin-1-yl)-N-isopropylpyridin-3-amine

Chemical Property of 2-(4-((1-benzyl-2-(methylthio)-2-[⁽¹⁴⁾C]-imidazol-5-yl)methyl)-piperazin-1-yl)-N-isopropylpyridin-3-amine

Chemical Property:

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Technology Process of 2-(4-((1-benzyl-2-(methylthio)-2-[⁽¹⁴⁾C]-imidazol-5-yl)methyl)-piperazin-1-yl)-N-isopropylpyridin-3-amine

There total 8 articles about 2-(4-((1-benzyl-2-(methylthio)-2-[⁽¹⁴⁾C]-imidazol-5-yl)methyl)-piperazin-1-yl)-N-isopropylpyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.5%

1-(1-benzyl-2-methylthio-2-[(14)C]-5-imidazoyl)-4-[3-(isopropylamino)-2-pyridyl]piperazine (1316754-21-8) → 2-(4-((1-benzyl-2-(methylthio)-2-[(14)C]-imidazol-5-yl)methyl)-piperazin-1-yl)-N-isopropylpyridin-3-amine (1316754-32-1)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; hexane; for 4h; Reflux;

DOI:10.1002/jlcr.1880

Reference yield:

1-benzyl-5-hydroxymethyl-2-methylthioimidazole-2-[(14)C] (1316754-22-9) → 2-(4-((1-benzyl-2-(methylthio)-2-[(14)C]-imidazol-5-yl)methyl)-piperazin-1-yl)-N-isopropylpyridin-3-amine (1316754-32-1)

Guidance literature:

Multi-step reaction with 4 steps

1: manganese(IV) oxide / chloroform / Reflux

2: silver nitrate; sodium hydroxide / water / 20 °C

3: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0 - 20 °C

4: diisobutylaluminium hydride / tetrahydrofuran; hexane / 4 h / Reflux

With manganese(IV) oxide; diisobutylaluminium hydride; silver nitrate; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; hexane; chloroform; water;

DOI:10.1002/jlcr.1880

Reference yield:

1-[1,1-dimethylethoxycarbonyl]-4-[3-amino-2-pyridinyl]piperazine (111669-25-1) → 2-(4-((1-benzyl-2-(methylthio)-2-[(14)C]-imidazol-5-yl)methyl)-piperazin-1-yl)-N-isopropylpyridin-3-amine (1316754-32-1)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium cyanoborohydride

2: trifluoroacetic acid

3: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0 - 20 °C

4: diisobutylaluminium hydride / tetrahydrofuran; hexane / 4 h / Reflux

With diisobutylaluminium hydride; sodium cyanoborohydride; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In tetrahydrofuran; hexane;

DOI:10.1002/jlcr.1880

upstream raw materials:

1-benzyl-2-methylthio-5-formylimidazole-2-[⁽¹⁴⁾C]

1-benzyl-2-methylthioimidazole-5-carboxylic acid-2-[⁽¹⁴⁾C]

[3-(1-methylethylamino)-2-pyridinyl]piperazine

1-(1-benzyl-2-methylthio-2-[⁽¹⁴⁾C]-5-imidazoyl)-4-[3-(isopropylamino)-2-pyridyl]piperazine

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