111669-25-1Relevant articles and documents
Oligomer modified diaromatic substituted compounds
-
, (2016/01/30)
Disclosed are compounds comprising diaromatic substituted compound residues, namely the anti-viral (anti-HIV) drug delavirdine, covalently attached via a linkage to water-soluble, non-peptidic oligomers, specifically to poly(ethylene glycol) (PEG) oligome
Strategy for 14C-labeling of a series of bis(heteroaryl) piperazines
Arjomandi, Omid Khalili,Saemian, Nader,Shirvani, Gholamhossein,Javaheri, Mohsen,Esmailli, Kameh
scheme or table, p. 363 - 366 (2012/06/04)
Four bis(heteroaryl)piperazines labeled with carbon-14 in the 2-position of imidazole moiety were prepared as part of a 4-step (or 5-step) sequence from 5-hydroxymethyl-2-mercapto-1-benzylimida-zole-[2-14C] as a key synthetic intermediate which
Synthesis and anti-HIV-1 activity of new delavirdine analogues carrying arylpyrrole moieties
Pinna,Loriga,Murineddu,Grella,Mura,Vargiu,Murgioni,La Colla
, p. 1406 - 1411 (2007/10/03)
In our search for novel anti-human immunodeficiency virus (HIV)-1 agents, 14 delavirdine analogues were synthesized and evaluated as potential anti-HIV-1 agents in cell-based assays. Compound 1Aa exhibited potent and selective anti-HIV-1 activity in acutely infected MT4 cells, with effective concentration (EC50) values in the submicromolar range.