methyl 1-(p-chlorobenzyl)-5-methyl-4-nitropyrazole-3-carboxylate

Base Information

• Chemical Name: methyl 1-(p-chlorobenzyl)-5-methyl-4-nitropyrazole-3-carboxylate
• CAS No.: 159427-52-8
• Molecular Formula: C₁₃H₁₂ClN₃O₄
• Molecular Weight: 309.709
• Mol file: 159427-52-8.mol

Synonyms:methyl 1-(p-chlorobenzyl)-5-methyl-4-nitropyrazole-3-carboxylate

Chemical Property of methyl 1-(p-chlorobenzyl)-5-methyl-4-nitropyrazole-3-carboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methyl 1-(p-chlorobenzyl)-5-methyl-4-nitropyrazole-3-carboxylate

There total 1 articles about methyl 1-(p-chlorobenzyl)-5-methyl-4-nitropyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methyl-4-nitro-1H-pyrazol-5-carboxylic acid methyl ester → methyl 1-(p-chlorobenzyl)-5-methyl-4-nitropyrazole-3-carboxylate (159427-52-8)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) reflux, 30 min, 2.) RT, 12 h;

DOI:10.1021/jm00051a009

Reference yield: 57.0%

methyl 1-(p-chlorobenzyl)-5-methyl-4-nitropyrazole-3-carboxylate (159427-52-8) → 1-(p-chlorobenzyl)-5-methyl-4-nitropyrazole-3-carboxylic acid (159427-57-3)

Guidance literature:

With potassium hydroxide; In methanol; Heating;

DOI:10.1021/jm00051a009

Reference yield:

methyl 1-(p-chlorobenzyl)-5-methyl-4-nitropyrazole-3-carboxylate (159427-52-8) → (S)-2-(4-Chloro-benzyl)-1-methyl-5,6,7,7a-tetrahydro-2H-2,3,4a,9-tetraaza-cyclopenta[f]azulen-4-one

Guidance literature:

Multi-step reaction with 4 steps

1: 57 percent / 1N aq. KOH / methanol / Heating

2: 1.) DMF, oxalyl chloride, 2.) triethylamine / 1.) benzene, 20 deg C, 3 h, 2.) THF, RT, 24 h

3: stannous chloride dihydrate / methanol / Heating

4: 47 percent / mercuric chloride, calcium carbonate / acetonitrile; H₂O / 24 h / Ambient temperature

With potassium hydroxide; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; calcium carbonate; mercury dichloride; tin(ll) chloride; In methanol; water; acetonitrile;

DOI:10.1021/jm00051a009

Downstream raw materials:

1-(p-chlorobenzyl)-5-methyl-4-nitropyrazole-3-carboxylic acid

[4-Amino-1-(4-chloro-benzyl)-5-methyl-1H-pyrazol-3-yl]-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone

(2S)-N-<<1-(p-chlorobenzyl)-5-methyl-4-nitropyrazol-3-yl>carbonyl>pyrrolidine-2-carboxaldehyde diethyl thioacetal