[4-Amino-1-(4-chloro-benzyl)-5-methyl-1H-pyrazol-3-yl]-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone

Base Information

• Chemical Name: [4-Amino-1-(4-chloro-benzyl)-5-methyl-1H-pyrazol-3-yl]-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone
• CAS No.: 1028263-83-3
• Molecular Formula: C₂₁H₂₉ClN₄OS₂
• Molecular Weight: 453.072
• Mol file: 1028263-83-3.mol

Synonyms:[4-Amino-1-(4-chloro-benzyl)-5-methyl-1H-pyrazol-3-yl]-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone

Chemical Property of [4-Amino-1-(4-chloro-benzyl)-5-methyl-1H-pyrazol-3-yl]-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-Amino-1-(4-chloro-benzyl)-5-methyl-1H-pyrazol-3-yl]-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone

There total 5 articles about [4-Amino-1-(4-chloro-benzyl)-5-methyl-1H-pyrazol-3-yl]-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-N-<<1-(p-chlorobenzyl)-5-methyl-4-nitropyrazol-3-yl>carbonyl>pyrrolidine-2-carboxaldehyde diethyl thioacetal (159427-70-0) → [4-Amino-1-(4-chloro-benzyl)-5-methyl-1H-pyrazol-3-yl]-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone (1028263-83-3)

Guidance literature:

With tin(ll) chloride; In methanol; Heating;

DOI:10.1021/jm00051a009

Reference yield:

(2S)-2-[di(ethylsulfanyl)methyl]tetrahydro-1H-pyrrole (105089-88-1) → [4-Amino-1-(4-chloro-benzyl)-5-methyl-1H-pyrazol-3-yl]-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone (1028263-83-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) DMF, oxalyl chloride, 2.) triethylamine / 1.) benzene, 20 deg C, 3 h, 2.) THF, RT, 24 h

2: stannous chloride dihydrate / methanol / Heating

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; tin(ll) chloride; In methanol;

DOI:10.1021/jm00051a009

Reference yield:

3-methyl-4-nitro-1H-pyrazol-5-carboxylic acid methyl ester → [4-Amino-1-(4-chloro-benzyl)-5-methyl-1H-pyrazol-3-yl]-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone (1028263-83-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NaH / 1.) reflux, 30 min, 2.) RT, 12 h

2: 57 percent / 1N aq. KOH / methanol / Heating

3: 1.) DMF, oxalyl chloride, 2.) triethylamine / 1.) benzene, 20 deg C, 3 h, 2.) THF, RT, 24 h

4: stannous chloride dihydrate / methanol / Heating

With potassium hydroxide; oxalyl dichloride; sodium hydride; triethylamine; N,N-dimethyl-formamide; tin(ll) chloride; In methanol;

DOI:10.1021/jm00051a009

upstream raw materials:

(2S)-N-<<1-(p-chlorobenzyl)-5-methyl-4-nitropyrazol-3-yl>carbonyl>pyrrolidine-2-carboxaldehyde diethyl thioacetal

(2S)-2-[di(ethylsulfanyl)methyl]tetrahydro-1H-pyrrole

1-(p-chlorobenzyl)-5-methyl-4-nitropyrazole-3-carboxylic acid

methyl 1-(p-chlorobenzyl)-5-methyl-4-nitropyrazole-3-carboxylate