(-)-1-Benzoyl-1,2,2a,3,4,5-hexahydrobenzindol-4-amine

Base Information

• Chemical Name: (-)-1-Benzoyl-1,2,2a,3,4,5-hexahydrobenzindol-4-amine
• CAS No.: 132619-30-8
• Molecular Formula: C₁₈H₁₈N₂O
• Molecular Weight: 278.354
• Mol file: 132619-30-8.mol

Synonyms:(-)-1-Benzoyl-1,2,2a,3,4,5-hexahydrobenzindol-4-amine

Chemical Property of (-)-1-Benzoyl-1,2,2a,3,4,5-hexahydrobenzindol-4-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-1-Benzoyl-1,2,2a,3,4,5-hexahydrobenzindol-4-amine

There total 3 articles about (-)-1-Benzoyl-1,2,2a,3,4,5-hexahydrobenzindol-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

Phenyl-[(5aS,6aR,7aS)-7-((S)-1-phenyl-ethyl)-5,5a,6,6a,7,7a-hexahydro-4,7-diaza-cyclopropa[e]acenaphthylen-4-yl]-methanone (132557-13-2,132619-32-0,141434-26-6) → Phenyl-(S)-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl-methanone + (-)-1-Benzoyl-1,2,2a,3,4,5-hexahydrobenzindol-4-amine (132619-30-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; under 760 Torr; elevated temperatures;

DOI:10.1016/S0040-4039(00)97303-9

Reference yield:

Phenyl-(5aS,6aS,7aR)-5a,6,6a,7a-tetrahydro-5H-7-oxa-4-aza-cyclopropa[e]acenaphthylen-4-yl-methanone (39890-59-0,124578-75-2,124578-76-3) → (-)-1-Benzoyl-1,2,2a,3,4,5-hexahydrobenzindol-4-amine (132619-30-8)

Guidance literature:

Multi-step reaction with 3 steps

1: butan-1-ol

2: DEAD, Ph₃P / or with Br₂/Ph₃P

3: H₂ / 10percent Pd/C / acetic acid / 760 Torr / 0 to 55 deg C

With hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In acetic acid; butan-1-ol;

DOI:10.1016/S0040-4039(00)97303-9

Reference yield:

[(2aS,4S,5S)-4-Hydroxy-5-((S)-1-phenyl-ethylamino)-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl]-phenyl-methanone (132619-31-9) → (-)-1-Benzoyl-1,2,2a,3,4,5-hexahydrobenzindol-4-amine (132619-30-8)

Guidance literature:

Multi-step reaction with 2 steps

1: DEAD, Ph₃P / or with Br₂/Ph₃P

2: H₂ / 10percent Pd/C / acetic acid / 760 Torr / 0 to 55 deg C

With hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In acetic acid;

DOI:10.1016/S0040-4039(00)97303-9

upstream raw materials:

Phenyl-[(5aS,6aR,7aS)-7-((S)-1-phenyl-ethyl)-5,5a,6,6a,7,7a-hexahydro-4,7-diaza-cyclopropa[e]acenaphthylen-4-yl]-methanone

Phenyl-(5aS,6aS,7aR)-5a,6,6a,7a-tetrahydro-5H-7-oxa-4-aza-cyclopropa[e]acenaphthylen-4-yl-methanone

[(2aS,4S,5S)-4-Hydroxy-5-((S)-1-phenyl-ethylamino)-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl]-phenyl-methanone

Downstream raw materials:

1-benzoyl-4-<<2-(cyclohexylcarbamoyl)ethyl>methylamino>-1,2,2a,3,4,5-hexahydrobenzindole

4-{[2-(cyclohexylcarbamoyl)ethyl]methylamino}-1,3,4,5-tetrahydrobenz(cd)indole

N-Cyclohexyl-3-((2aS,4R)-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-4-yl-methyl-amino)-propionamide