Methanesulfonic acid (1R,2R,6R)-2-[(S)-2-(5-bromo-furan-2-yl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-6-isopropyl-3-methyl-cyclohex-3-enylmethyl ester

Base Information

Chemical Name:Methanesulfonic acid (1R,2R,6R)-2-[(S)-2-(5-bromo-furan-2-yl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-6-isopropyl-3-methyl-cyclohex-3-enylmethyl ester
CAS No.:204375-24-6
Molecular Formula:C₃₄H₄₅BrO₅SSi
Molecular Weight:673.784
Hs Code.:

Methanesulfonic acid (1R,2R,6R)-2-[(S)-2-(5-bromo-furan-2-yl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-6-isopropyl-3-methyl-cyclohex-3-enylmethyl ester

Synonyms:Methanesulfonic acid (1R,2R,6R)-2-[(S)-2-(5-bromo-furan-2-yl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-6-isopropyl-3-methyl-cyclohex-3-enylmethyl ester

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Chemical Property of Methanesulfonic acid (1R,2R,6R)-2-[(S)-2-(5-bromo-furan-2-yl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-6-isopropyl-3-methyl-cyclohex-3-enylmethyl ester

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Technology Process of Methanesulfonic acid (1R,2R,6R)-2-[(S)-2-(5-bromo-furan-2-yl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-6-isopropyl-3-methyl-cyclohex-3-enylmethyl ester

There total 8 articles about Methanesulfonic acid (1R,2R,6R)-2-[(S)-2-(5-bromo-furan-2-yl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-6-isopropyl-3-methyl-cyclohex-3-enylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 124-63-0
methanesulfonyl chloride

: 204375-23-5
{(1R,2R,6R)-2-[(S)-2-(5-Bromo-furan-2-yl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-6-isopropyl-3-methyl-cyclohex-3-enyl}-methanol

: 204375-24-6
Methanesulfonic acid (1R,2R,6R)-2-[(S)-2-(5-bromo-furan-2-yl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-6-isopropyl-3-methyl-cyclohex-3-enylmethyl ester

Guidance literature:: With pyridine; dmap; at 0 ℃;

Reference yield:

: 204375-29-1
(1R,5R,6R)-5-Isopropyl-2-methyl-bicyclo[4.2.0]oct-2-en-7-one

: 204375-24-6
Methanesulfonic acid (1R,2R,6R)-2-[(S)-2-(5-bromo-furan-2-yl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-6-isopropyl-3-methyl-cyclohex-3-enylmethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 66 percent / 3 h / 60 °C

2: p-TsOH*H₂O / 4 h / 60 °C

3: p-TsOH*H₂O, acetone / 1 h

4: 1.) n-BuLi / 1.) THF, -78 deg C, 10 min, 2.) THF, -78 deg C, 1 h

5: 97 percent / imidazole / CH₂Cl₂ / 4 h / 25 °C

6: 99 percent / DIBAL / toluene; hexane / 1 h / -78 °C

7: 92 percent / pyridine, DMAP / 4 h / 25 °C

With pyridine; 1H-imidazole; dmap; n-butyllithium; diisobutylaluminium hydride; toluene-4-sulfonic acid; acetone; In hexane; dichloromethane; toluene;
DOI:10.1021/ja990215c

Reference yield:

: 204375-33-7
(1R,2R,6R)-2-[(S)-2-(5-Bromo-furan-2-yl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-6-isopropyl-3-methyl-cyclohex-3-enecarboxylic acid methyl ester

: 204375-24-6
Methanesulfonic acid (1R,2R,6R)-2-[(S)-2-(5-bromo-furan-2-yl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-6-isopropyl-3-methyl-cyclohex-3-enylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / DIBAL / toluene; hexane / 1 h / -78 °C

2: 92 percent / pyridine, DMAP / 4 h / 25 °C

With pyridine; dmap; diisobutylaluminium hydride; In hexane; toluene;
DOI:10.1021/ja990215c