5,6-Diamino-8-benzylsulfanyl-1-cyclopropyl-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

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Chemical Name:5,6-Diamino-8-benzylsulfanyl-1-cyclopropyl-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester
CAS No.:161040-94-4
Molecular Formula:C₂₇H₃₃N₅O₃S
Molecular Weight:507.657
Hs Code.:

Synonyms:5,6-Diamino-8-benzylsulfanyl-1-cyclopropyl-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

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Chemical Property of 5,6-Diamino-8-benzylsulfanyl-1-cyclopropyl-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

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Technology Process of 5,6-Diamino-8-benzylsulfanyl-1-cyclopropyl-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

There total 8 articles about 5,6-Diamino-8-benzylsulfanyl-1-cyclopropyl-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 100-53-8
phenylmethanethiol

: 148927-16-6
ethyl 1-cyclopropyl-5,6-diamino-8-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate

: 161040-94-4
5,6-Diamino-8-benzylsulfanyl-1-cyclopropyl-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 1h; Ambient temperature;
DOI:10.1021/jm00006a017

Reference yield:

: 109-01-3
1-methyl-piperazine

: 161040-94-4
5,6-Diamino-8-benzylsulfanyl-1-cyclopropyl-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 33 percent / toluene / 5 h / Ambient temperature

2: 54 percent / HMPA / 45 °C

3: 39 percent / 36 h / 140 °C

4: 79 percent / polyphosphoric acid / 2 h / 90 °C

5: 95 percent / 30percent NH₄OH / ethanol / 0.83 h / 80 °C

6: 52 percent / H₂ / Raney Ni / ethanol / 1 h / 760 Torr / Ambient temperature

7: 79 percent / NaH / tetrahydrofuran / 1 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; ammonium hydroxide; PPA; hydrogen; sodium hydride; nickel; In tetrahydrofuran; ethanol; toluene;
DOI:10.1021/jm00006a017

Reference yield:

: 314-41-0
1,2,3,5-tetrafluoro-4-nitrobenzene

: 161040-94-4
5,6-Diamino-8-benzylsulfanyl-1-cyclopropyl-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 33 percent / toluene / 5 h / Ambient temperature

2: 54 percent / HMPA / 45 °C

3: 39 percent / 36 h / 140 °C

4: 79 percent / polyphosphoric acid / 2 h / 90 °C

5: 95 percent / 30percent NH₄OH / ethanol / 0.83 h / 80 °C

6: 52 percent / H₂ / Raney Ni / ethanol / 1 h / 760 Torr / Ambient temperature

7: 79 percent / NaH / tetrahydrofuran / 1 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; ammonium hydroxide; PPA; hydrogen; sodium hydride; nickel; In tetrahydrofuran; ethanol; toluene;
DOI:10.1021/jm00006a017