314-41-0

Basic information

• Product Name: 2,3,4,6-TETRAFLUORONITROBENZENE
• Synonyms: 1,2,3,5-Tetrafluoro-4-nitrobenzene;Benzene, 1,2,3,5-tetrafluoro-4-nitro-;2,3,4,6-TETRAFLUORONITROBENZENE;2,3,4,6-TETRAFLUORONITROBENZENE, 97+%;5-fluro-2-methylaniline;2,3,4,6-Tetrafluoronitrobenzene 98%;2,3,4,6-Tetrafluoronitrobenzene98%;1-Nitro-2,3,4,6-tetrafluorobenzene
• CAS NO: 314-41-0
• Molecular Formula: C₆HF₄NO₂
• Molecular Weight: 195.07
• EINECS: 206-246-7
• Product Categories: Benzene series;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks
• Mol File: 314-41-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: -5
• Boiling Point: 78-79°C 20mm
• Flash Point: 160 °F
• Appearance: yellow liquid
• Density: 1.511 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: n20/D 1.464(lit.)
• Storage Temp.: 2-8°C
• Stability: Stable. Incompatible with strong oxidizing agents, strong bases. Combustible.
• CAS DataBase Reference: 2,3,4,6-TETRAFLUORONITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,6-TETRAFLUORONITROBENZENE(314-41-0)
• EPA Substance Registry System: 2,3,4,6-TETRAFLUORONITROBENZENE(314-41-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 314-41-0(Hazardous Substances Data)

Usage

Chemical Properties

yellow liquid

General Description

Molluscicidal activity of 2,3,4,6-tetrafluoronitrobenzene against Biomphalaria glabrata has been investigated. Palladium-catalyzed cross-coupling reactions of 2,3,4,6-tetrafluoronitrobenzene with alkyne derivatives has been studied. Reaction of 2,3,4,6-tetrafluoronitrobenzene with 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene in the presence of water molecules in acetonitrile has been investigated.

InChI:InChI=1/C8H7FO2/c1-5-3-2-4-6(7(5)9)8(10)11/h2-4H,1H3,(H,10,11)

Upstream product

• 2367-82-0 1,2,3,5-tetrafluorobenzene 

Downstream Products

• 66684-68-2 1,2,5-Trifluor-3-methoxy-4-nitrobenzol 
• 66684-67-1 1,3,4-trifluoro-5-methoxy-2-nitrobenzene 
• 17826-68-5 1-bromo-2,3,4,6-tetrafluoro-5-nitrobenzene 
• 71451-49-5 1,2,3,5-tetrafluoro-4-iodo-6-nitrobenzene 
• 5415-62-3 2,3,5-trifluoro-6-nitroaniline 
• 363-73-5 2,3,4,6-tetrafluoroaniline 
• 148927-13-3 3,4,6-trifluoro-2-(4-methyl-1-piperazinyl)-nitrobenzene 
• 765962-71-8 (2-fluoro-4-iodo-phenyl)-(2,3,5-trifluoro-6-nitro-phenyl)-amine 
• 923294-32-0 2,4,5,6-tetrafluoro-3-iodophenylnitrene 
• 923294-26-2 3-iodo-2,4,5,6-tetrafluoroazidobenzene 
• 923294-22-8 3-iodo-2,4,5,6-tetrafluoroaniline 

Relevant articles and documents

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HETEROCYCLIC SULFONAMIDE DERIVATIVES

The present invention relates to compounds (I) and pharmaceutically acceptable salts thereof. The compounds have been demonstrated as inhibitors of MEK and therefore may be useful in the treatment of hyperproliferative diseases like cancer and inflammation.

Nitration of Strongly Deactivated Aromatics with Superacidic Mixed Nitric-Triflatoboric Acid (HNO3/2CF3SO3H-B(O3SCF3)3)

The nitration of various deactivated arenes (including methanesulfonyl-, nitro-, and polyhalobenzenes) was carried out in good yield with mixed nitric-triflatoboric superacid.For example pentafluorobenzene gave pentafluoronitrobenzene in 99percent yield, nitrobenzene to m-dinitrobenzene in 92percent selectivity with 85percent overall yield, and methyl phenyl sulfone gave only the m-nitro isomer in 78percent isolated yield.Thus the new nitrating system gives high regioselectivity and yields under generally mild reaction conditions.The reagent system is compatible with many functional groups of arenes.