(E)-tert-butyl 2-(methylcarbamoyl)-4-(3-(2,6,6-trimethylcyclohex-1-en-1-yl)acryloyl)piperazine-1-carboxylate

Base Information

Chemical Name:(E)-tert-butyl 2-(methylcarbamoyl)-4-(3-(2,6,6-trimethylcyclohex-1-en-1-yl)acryloyl)piperazine-1-carboxylate
CAS No.:1259014-02-2
Molecular Formula:C₂₃H₃₇N₃O₄
Molecular Weight:419.564
Hs Code.:

Synonyms:(E)-tert-butyl 2-(methylcarbamoyl)-4-(3-(2,6,6-trimethylcyclohex-1-en-1-yl)acryloyl)piperazine-1-carboxylate

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Chemical Property of (E)-tert-butyl 2-(methylcarbamoyl)-4-(3-(2,6,6-trimethylcyclohex-1-en-1-yl)acryloyl)piperazine-1-carboxylate

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Technology Process of (E)-tert-butyl 2-(methylcarbamoyl)-4-(3-(2,6,6-trimethylcyclohex-1-en-1-yl)acryloyl)piperazine-1-carboxylate

There total 5 articles about (E)-tert-butyl 2-(methylcarbamoyl)-4-(3-(2,6,6-trimethylcyclohex-1-en-1-yl)acryloyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 14393-45-4
(E)-3-(2,6,6-trimethylcyclohex-1-enyl)acrylic acid

: 1259014-01-1
tert-butyl 2-(methylcarbamoyl)piperazine-1-carboxylate

: 1259014-02-2
(E)-tert-butyl 2-(methylcarbamoyl)-4-(3-(2,6,6-trimethylcyclohex-1-en-1-yl)acryloyl)piperazine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; acetonitrile; at 20 ℃; for 18h; Inert atmosphere;

Reference yield:

: 149057-19-2
4-((benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid

: 1259014-02-2
(E)-tert-butyl 2-(methylcarbamoyl)-4-(3-(2,6,6-trimethylcyclohex-1-en-1-yl)acryloyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / 760.05 Torr / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; acetonitrile / 18 h / 20 °C / Inert atmosphere

With hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 2762-32-5
piperazine-2-carboxylic acid

: 1259014-02-2
(E)-tert-butyl 2-(methylcarbamoyl)-4-(3-(2,6,6-trimethylcyclohex-1-en-1-yl)acryloyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 0.75 h / 20 °C / pH 9.5 - 11

1.2: 17 h / 20 °C / pH 9.5

1.3: pH 2

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / 760.05 Torr / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; acetonitrile / 18 h / 20 °C / Inert atmosphere

With hydrogen; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;