2762-32-5

Usage

Uses

Used in Pharmaceutical Industry:
2-Piperazinecarboxylic acid dihydrochloride is used as an antimalarial drug for the treatment of malaria. It is effective in killing the parasites responsible for the disease and is a valuable tool in the fight against malaria.
Used in Malaria Treatment:
2-Piperazinecarboxylic acid dihydrochloride is used as a drug candidate for the treatment of malaria. It is effective against drug-resistant strains of malaria and has a long half-life, making it a promising alternative to other antimalarial drugs.
Used in Combination Therapy:
2-Piperazinecarboxylic acid dihydrochloride is used in combination therapy for the treatment of malaria. Studies have shown that it is effective in combination with other antimalarial drugs, enhancing the overall treatment efficacy.
Used in Pharmaceutical Formulations:
2-Piperazinecarboxylic acid dihydrochloride is used as a stable and water-soluble salt in pharmaceutical formulations. Its dihydrochloride form makes it suitable for use in various drug delivery systems, improving the bioavailability and therapeutic outcomes of the drug.

InChI:InChI:1S/C5H10N2O2/c8-5(9)4-3-6-1-2-7-4/h4,6-7H,1-3H2,(H,8,9)

Upstream product

• 98-97-5 2-pyrazylcarboxylic acid 
• 77873-75-7 N-N-diacetyl-2-cyanopiperazine 

Downstream Products

• 147650-70-2 (2S)-piperazine-2-carboxylic acid 
• 128019-59-0 piperazine-1,3-dicarboxylic acid 1-tert-butyl ester 
• 181955-79-3 N,N'-di-tert-butyloxycarbonylpiperazine-2-carboxylic acid 
• 934630-06-5 4-(benzyloxy-carbonyl)-2-piperazinecarboxylic acid 
• 171504-98-6 O₁,O₄-di-tert-butyl O₂-methyl piperazine-1,2,4-tricarboxylate 
• 1092478-40-4 (+/-)-bis(1,1-dimethylethyl) 2-[3-(ethyloxy)-3-oxopropyl]-2-methyl-1,4-piperazinedicarboxylate 
• 100828-16-8 4-(3-phosphonopropyl)-2-piperazinecarboxylic acid 
• 317365-33-6 1-(benzyloxycarbonyl)-2-hydroxymethyl-4-(tert-butyloxycarbonyl)-piperazine 
• 126937-42-6 piperazine-1,2,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester 2-methyl ester 
• 126937-44-8 2-methyl 1-phenylmethyl 1,2-piperazinedicarboxilate, trifluoroacetate 
• 126937-45-9 2-methyl 1-(phenylmethyl) (+/-)-4-<3-(diethoxyphosphinyl)propyl>-1,2-piperazinedicarboxylate 

Relevant academic research and scientific papers

Heterocyclic substituted aniline calcium channel blockers

The present invention provides compounds that block calcium channels having the Formula I shown below. STR1The present invention also provides methods of using the compounds of Formula I to treat stroke, cerebral ischemia, head trauma, epilepsy, asthma, amyotrophic lateral sclerosis, or pain and to pharmaceutical compositions that contain the compounds of Formula I.

Synthesis and biological evaluation of substituted 4-(OBz)phenylalanine derivatives as novel N-type calcium channel blockers

Selective N-type Voltage Activated Calcium Channel (VACC) blockers have shown utility in several models of stroke and pain. In the process of searching for small molecules as N-type calcium channel blockers, we have identified a series of N,N-dialkylpeptidylamines (e.g., PD 175069) with potent functional activity at N-type VACC. Further modification of the leucine moiety of PD 175069 with a cyclized ring structure provides a series of novel molecules. Syntheses and pharmacological evaluation of the series are presented.

NEW SYNTHESIS OF PIPECOLIC ACID AND ANALOGS

Pipecolic acid congeners are synthesised from α-cyanoamides, obtained by substitution of α-methoxyamides with trimethylsilyl cyanide and in an alternative route via oxidation of amidoalkylationproducts of the α-methoxyamides.