2-(((2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzonitrile

Base Information

• Chemical Name: 2-(((2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzonitrile
• CAS No.: 1020252-22-5
• Molecular Formula: C₁₄H₁₂N₂O₄
• Molecular Weight: 272.26
• DSSTox Substance ID: DTXSID801144401
• Mol file: 1020252-22-5.mol

Synonyms:1020252-22-5;2-(((2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzonitrile;2-[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methylamino]benzonitrile;2-(((4,4-DIMETHYL-2,6-DIOXO-3,5-DIOXANYLIDENE)METHYL)AMINO)BENZENECARBONITRILE;2-{[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl]amino}benzonitrile;2-[(2,2-DiMethyl-4,6-dioxo-[1,3]dioxan-5-ylideneMethyl)-aMino]-benzonitrile;2-[[(2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl]amino]benzonitrile;SCHEMBL4017148;DTXSID801144401;MFCD00170562;AKOS005110490;MS-6464;CS-0153775;F14986

Chemical Property of 2-(((2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzonitrile

Chemical Property:

• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 272.07970687
• Heavy Atom Count: 20
• Complexity: 479

Purity/Quality:

99% ^*data from raw suppliers

2-(((2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(OC(=O)C(=CNC2=CC=CC=C2C#N)C(=O)O1)C

Technology Process of 2-(((2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzonitrile

There total 2 articles about 2-(((2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-methoxymethylene-2,2-dimethyl-1,3-dioxane-4,6-dione (15568-85-1) + anthranilic acid nitrile (1885-29-6) → 2-{[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl]amino}benzonitrile (1020252-22-5)

Guidance literature:

In acetonitrile; at 20 ℃; for 0.25h;

DOI:10.1055/s-0029-1217383

Reference yield:

cycl-isopropylidene malonate (2033-24-1) → 2-{[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl]amino}benzonitrile (1020252-22-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1 h / Heating

2: dimethylformamide / 2 h / Heating

In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2004.12.037

Reference yield:

2-{[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl]amino}benzonitrile (1020252-22-5) → 4-hydroxy-8-cyanoquinoline (848128-91-6,127285-55-6)

Guidance literature:

In diphenylether; at 300 ℃; for 0.0833333h; microwave irradiation;

DOI:10.1016/j.bmcl.2004.12.037

upstream raw materials:

5-methoxymethylene-2,2-dimethyl-1,3-dioxane-4,6-dione

anthranilic acid nitrile

cycl-isopropylidene malonate

Downstream raw materials:

4-hydroxy-8-cyanoquinoline

4-chloro-8-cyanoquinoline