ethyl 2-[3-[[2-chloro-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenoxy]acetate

Base Information

Chemical Name:ethyl 2-[3-[[2-chloro-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenoxy]acetate
CAS No.:1427407-13-3
Molecular Formula:C₂₃H₁₉ClF₃NO₃
Molecular Weight:449.857
Hs Code.:

Synonyms:ethyl 2-[3-[[2-chloro-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenoxy]acetate

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Chemical Property of ethyl 2-[3-[[2-chloro-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenoxy]acetate

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Technology Process of ethyl 2-[3-[[2-chloro-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenoxy]acetate

There total 6 articles about ethyl 2-[3-[[2-chloro-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenoxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1427407-12-2
3-[[2-chloro-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluoro-phenol

: 105-36-2
ethyl bromoacetate

: 1427407-13-3
ethyl 2-[3-[[2-chloro-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenoxy]acetate

Guidance literature:: 3-[[2-chloro-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluoro-phenol; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

ethyl bromoacetate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 1183702-65-9
2-chloro-5-(3-fluorophenyl)benzoic acid

: 1427407-13-3
ethyl 2-[3-[[2-chloro-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenoxy]acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2.1: sodium hydrogencarbonate / tetrahydrofuran / 0.5 h / 20 °C

3.1: borane-THF / tetrahydrofuran / 3 h / 60 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 3 h / 20 °C

With borane-THF; oxalyl dichloride; sodium hydrogencarbonate; caesium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: C₁₃H₇Cl₂FO

: 1427407-13-3
ethyl 2-[3-[[2-chloro-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenoxy]acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran / 0.5 h / 20 °C

2.1: borane-THF / tetrahydrofuran / 3 h / 60 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 3 h / 20 °C

With borane-THF; sodium hydrogencarbonate; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;