tert-butyl (1S,2R)-2-hydroxy-3-(phenylsulfonyl)cyclohex-3-enylcarbamate

Base Information

• Chemical Name: tert-butyl (1S,2R)-2-hydroxy-3-(phenylsulfonyl)cyclohex-3-enylcarbamate
• CAS No.: 1043476-17-0
• Molecular Formula: C₁₇H₂₃NO₅S
• Molecular Weight: 353.439
• Mol file: 1043476-17-0.mol

Synonyms:tert-butyl (1S,2R)-2-hydroxy-3-(phenylsulfonyl)cyclohex-3-enylcarbamate

Chemical Property of tert-butyl (1S,2R)-2-hydroxy-3-(phenylsulfonyl)cyclohex-3-enylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (1S,2R)-2-hydroxy-3-(phenylsulfonyl)cyclohex-3-enylcarbamate

There total 1 articles about tert-butyl (1S,2R)-2-hydroxy-3-(phenylsulfonyl)cyclohex-3-enylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(1S,3R,4R)-tert-butyl 2-hydroxy-3-(phenylsulfonyl)-7-azabicyclo[2.2.1]heptane-7-carboxylate (1043476-05-6) → tert-butyl (1S,2R)-2-hydroxy-3-(phenylsulfonyl)cyclohex-3-enylcarbamate (1043476-17-0)

Guidance literature:

With methylmagnesium bromide; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ol801381t

Reference yield:

tert-butyl (1S,2R)-2-hydroxy-3-(phenylsulfonyl)cyclohex-3-enylcarbamate (1043476-17-0) → (1S,2S)-trans-2-aminocyclohexanol (931-15-7,931-16-8,6850-38-0,6982-39-4,33092-82-9,38898-70-3,74111-21-0,108267-20-5)

Guidance literature:

tert-butyl (1S,2R)-2-hydroxy-3-(phenylsulfonyl)cyclohex-3-enylcarbamate; With disodium hydrogenphosphate; sodium amalgam; In tetrahydrofuran; methanol;

With palladium on activated charcoal; hydrogen; In methanol;

With trifluoroacetic acid; In dichloromethane;

DOI:10.1021/ol801381t

upstream raw materials:

(1S,3R,4R)-tert-butyl 2-hydroxy-3-(phenylsulfonyl)-7-azabicyclo[2.2.1]heptane-7-carboxylate

Downstream raw materials:

(1S,2S)-trans-2-aminocyclohexanol