ethyl <5-amino-3-(3-bromophenyl)-1,2-dihydro-2(S)-methylpyrido<3,4-b>pyrazin-7-yl>carbamate

Base Information

Chemical Name:ethyl <5-amino-3-(3-bromophenyl)-1,2-dihydro-2(S)-methylpyrido<3,4-b>pyrazin-7-yl>carbamate
CAS No.:154321-07-0
Molecular Formula:C₁₇H₁₈BrN₅O₂
Molecular Weight:404.266
Hs Code.:

Synonyms:ethyl <5-amino-3-(3-bromophenyl)-1,2-dihydro-2(S)-methylpyrido<3,4-b>pyrazin-7-yl>carbamate

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Chemical Property of ethyl <5-amino-3-(3-bromophenyl)-1,2-dihydro-2(S)-methylpyrido<3,4-b>pyrazin-7-yl>carbamate

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Technology Process of ethyl <5-amino-3-(3-bromophenyl)-1,2-dihydro-2(S)-methylpyrido<3,4-b>pyrazin-7-yl>carbamate

There total 6 articles about ethyl <5-amino-3-(3-bromophenyl)-1,2-dihydro-2(S)-methylpyrido<3,4-b>pyrazin-7-yl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 154321-06-9
ethyl <6-amino-4-<<2-(3-bromophenyl)-1-methyl-2-oxoethyl>amino>-5-nitro-2-pyridinyl>carbamate

: 154321-07-0
ethyl <5-amino-3-(3-bromophenyl)-1,2-dihydro-2(S)-methylpyrido<3,4-b>pyrazin-7-yl>carbamate

Guidance literature:: With iron; acetic acid; In ethanol; for 3.5h; Heating;
DOI:10.1002/jlcr.2580340103

Reference yield:

: 108-36-1
1,3-dibromobenzene

: 154321-07-0
ethyl <5-amino-3-(3-bromophenyl)-1,2-dihydro-2(S)-methylpyrido<3,4-b>pyrazin-7-yl>carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi / 1.) ether, -110 deg C, 0.5 h, 2.) ether, from -110 deg C to -10 deg C

2: NaBH₄ / methanol / 0.5 h / Ambient temperature

3: KOH / methanol; H₂O / 2 h / Heating

4: 30 percent / Et₃N / ethanol / 24 h / Heating

5: 66 percent / CrO₃, pyridine / CH₂Cl₂ / 2 h / Ambient temperature

6: 98 percent / Fe, glacial AcOH / ethanol / 3.5 h / Heating

With pyridine; chromium(VI) oxide; potassium hydroxide; sodium tetrahydroborate; n-butyllithium; iron; acetic acid; triethylamine; In methanol; ethanol; dichloromethane; water;
DOI:10.1002/jlcr.2580340103

Reference yield:

: α-(1-aminoethyl)-3-bromobenzenemethanol

: 154321-07-0
ethyl <5-amino-3-(3-bromophenyl)-1,2-dihydro-2(S)-methylpyrido<3,4-b>pyrazin-7-yl>carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 30 percent / Et₃N / ethanol / 24 h / Heating

2: 66 percent / CrO₃, pyridine / CH₂Cl₂ / 2 h / Ambient temperature

3: 98 percent / Fe, glacial AcOH / ethanol / 3.5 h / Heating

With pyridine; chromium(VI) oxide; iron; acetic acid; triethylamine; In ethanol; dichloromethane;
DOI:10.1002/jlcr.2580340103