(S,S)-5,5'-bis-(4-(6-(2-tert-butoxycarbonylamino-3-phenylpropanoyloxy)hexyloxy)phenyl)-[2,2']-bithiophene

Base Information

Chemical Name:(S,S)-5,5'-bis-(4-(6-(2-tert-butoxycarbonylamino-3-phenylpropanoyloxy)hexyloxy)phenyl)-[2,2']-bithiophene
CAS No.:1262996-44-0
Molecular Formula:C₆₀H₇₂N₂O₁₀S₂
Molecular Weight:1045.37
Hs Code.:

Synonyms:(S,S)-5,5'-bis-(4-(6-(2-tert-butoxycarbonylamino-3-phenylpropanoyloxy)hexyloxy)phenyl)-[2,2']-bithiophene

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Chemical Property of (S,S)-5,5'-bis-(4-(6-(2-tert-butoxycarbonylamino-3-phenylpropanoyloxy)hexyloxy)phenyl)-[2,2']-bithiophene

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Technology Process of (S,S)-5,5'-bis-(4-(6-(2-tert-butoxycarbonylamino-3-phenylpropanoyloxy)hexyloxy)phenyl)-[2,2']-bithiophene

There total 4 articles about (S,S)-5,5'-bis-(4-(6-(2-tert-butoxycarbonylamino-3-phenylpropanoyloxy)hexyloxy)phenyl)-[2,2']-bithiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1046451-11-9
(S)-4-iodo-1-(6-(2-tert-butoxycarbonylamino-3-phenylpropanoyloxy)hexyloxy)benzene

: 239075-02-6
5,5'-di(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-2,2'-bithiophene

: 1262996-44-0
(S,S)-5,5'-bis-(4-(6-(2-tert-butoxycarbonylamino-3-phenylpropanoyloxy)hexyloxy)phenyl)-[2,2']-bithiophene

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; silver(l) oxide; In 1,4-dioxane; at 70 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2010.11.004

Reference yield:

: 4286-55-9
1-bromo-6-hexanol

: 1262996-44-0
(S,S)-5,5'-bis-(4-(6-(2-tert-butoxycarbonylamino-3-phenylpropanoyloxy)hexyloxy)phenyl)-[2,2']-bithiophene

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.17 h / Inert atmosphere

1.2: 8 h / Inert atmosphere

2.1: dmap; Isopropenyl chloroformate; triethylamine / dichloromethane / 1.5 h / 0 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; silver(l) oxide / 1,4-dioxane / 70 °C / Inert atmosphere

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Isopropenyl chloroformate; sodium carbonate; triethylamine; potassium hydroxide; silver(l) oxide; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; 3.1: Suzuki-Miyaura coupling;
DOI:10.1016/j.tet.2010.11.004

Reference yield:

: 540-38-5
p-Iodophenol

: 1262996-44-0
(S,S)-5,5'-bis-(4-(6-(2-tert-butoxycarbonylamino-3-phenylpropanoyloxy)hexyloxy)phenyl)-[2,2']-bithiophene

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.17 h / Inert atmosphere

1.2: 8 h / Inert atmosphere

2.1: dmap; Isopropenyl chloroformate; triethylamine / dichloromethane / 1.5 h / 0 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; silver(l) oxide / 1,4-dioxane / 70 °C / Inert atmosphere

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Isopropenyl chloroformate; sodium carbonate; triethylamine; potassium hydroxide; silver(l) oxide; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; 3.1: Suzuki-Miyaura coupling;
DOI:10.1016/j.tet.2010.11.004