7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-indan-5-yl)-heptanoic acid methyl ester

Base Information

Chemical Name:7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-indan-5-yl)-heptanoic acid methyl ester
CAS No.:121099-91-0
Molecular Formula:C₂₅H₃₁FO₃
Molecular Weight:398.518
Hs Code.:

Synonyms:7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-indan-5-yl)-heptanoic acid methyl ester

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Chemical Property of 7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-indan-5-yl)-heptanoic acid methyl ester

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Technology Process of 7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-indan-5-yl)-heptanoic acid methyl ester

There total 4 articles about 7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-indan-5-yl)-heptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57122-11-9
6-methoxy-4,7-dimethyl-2,3-dihydro-1H-inden-1-one

: 121099-91-0
7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-indan-5-yl)-heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / NaBH₄ / methanol; tetrahydrofuran / 1 h / Ambient temperature

2: 96 percent / H₂ / palladium black / acetic acid / 3 h / Ambient temperature

3: 99 percent / BBr₃ / CH₂Cl₂ / 1 h / Ambient temperature

4: BF₃*Et₂O / 1,2-dichloro-ethane / 6 h / 60 °C

With sodium tetrahydroborate; boron trifluoride diethyl etherate; hydrogen; boron tribromide; palladium; In tetrahydrofuran; methanol; dichloromethane; acetic acid; 1,2-dichloro-ethane;
DOI:10.1021/jm00090a009

Reference yield:

: 140875-09-8
6-methoxy-4,7-dimethyl-1-indanol

: 121099-91-0
7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-indan-5-yl)-heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / H₂ / palladium black / acetic acid / 3 h / Ambient temperature

2: 99 percent / BBr₃ / CH₂Cl₂ / 1 h / Ambient temperature

3: BF₃*Et₂O / 1,2-dichloro-ethane / 6 h / 60 °C

With boron trifluoride diethyl etherate; hydrogen; boron tribromide; palladium; In dichloromethane; acetic acid; 1,2-dichloro-ethane;
DOI:10.1021/jm00090a009