2-amino-1-(2-(4-fluorophenyl)-3-(4-fluorophenylamino)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-ethanone

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Chemical Name:2-amino-1-(2-(4-fluorophenyl)-3-(4-fluorophenylamino)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-ethanone
CAS No.:1261109-90-3
Molecular Formula:C₂₀H₁₉F₂N₅O
Molecular Weight:383.401
Hs Code.:

Synonyms:2-amino-1-(2-(4-fluorophenyl)-3-(4-fluorophenylamino)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-ethanone

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Chemical Property of 2-amino-1-(2-(4-fluorophenyl)-3-(4-fluorophenylamino)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-ethanone

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Technology Process of 2-amino-1-(2-(4-fluorophenyl)-3-(4-fluorophenylamino)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-ethanone

There total 6 articles about 2-amino-1-(2-(4-fluorophenyl)-3-(4-fluorophenylamino)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1312945-44-0
C₂₅H₂₇F₂N₅O₃

: 1261109-90-3
2-amino-1-(2-(4-fluorophenyl)-3-(4-fluorophenylamino)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-ethanone

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1021/jm2003359

Reference yield:

: 1261110-12-6
N,2-bis(4-fluorophenyl)imidazo[1,2-a]pyrazin-3-amine

: 1261109-90-3
2-amino-1-(2-(4-fluorophenyl)-3-(4-fluorophenylamino)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: palladium on carbon; hydrogen / methanol / 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

3: trifluoroacetic acid / dichloromethane / 20 °C

With palladium on carbon; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm2003359

Reference yield:

: 24075-34-1
4-fluorophenyl isocyanide

: 1261109-90-3
2-amino-1-(2-(4-fluorophenyl)-3-(4-fluorophenylamino)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: perchloric acid / methanol / 20 °C

2: palladium on carbon; hydrogen / methanol / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

4: trifluoroacetic acid / dichloromethane / 20 °C

With perchloric acid; palladium on carbon; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; 1: Ugi condensation;
DOI:10.1021/jm2003359