4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]-1'-(tert-butoxycarbonyl)-4'-methyl-1,4'-bipiperidine

Base Information

Chemical Name:4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]-1'-(tert-butoxycarbonyl)-4'-methyl-1,4'-bipiperidine
CAS No.:305794-43-8
Molecular Formula:C₂₅H₃₇BrN₂O₄
Molecular Weight:509.484
Hs Code.:

Synonyms:4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]-1'-(tert-butoxycarbonyl)-4'-methyl-1,4'-bipiperidine

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Chemical Property of 4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]-1'-(tert-butoxycarbonyl)-4'-methyl-1,4'-bipiperidine

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Technology Process of 4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]-1'-(tert-butoxycarbonyl)-4'-methyl-1,4'-bipiperidine

There total 8 articles about 4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]-1'-(tert-butoxycarbonyl)-4'-methyl-1,4'-bipiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 305794-42-7
4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]-1'-(tert-butoxycarbonyl)-4'-cyano-1,4'-bipiperidine

: 305794-43-8
4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]-1'-(tert-butoxycarbonyl)-4'-methyl-1,4'-bipiperidine

Guidance literature:: With methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 20 ℃; for 2h;
DOI:10.1021/jm0200815

Reference yield: 98.0%

: 75-16-1
methylmagnesium bromide

: 305794-42-7
4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]-1'-(tert-butoxycarbonyl)-4'-cyano-1,4'-bipiperidine

: 305794-43-8
4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]-1'-(tert-butoxycarbonyl)-4'-methyl-1,4'-bipiperidine

Guidance literature:: In tetrahydrofuran; diethyl ether; at 20 ℃; for 2h;
DOI:10.1021/jm015526o

Reference yield:

: 126501-71-1
1-(2,2,2-trifluoroacetyl)piperidine-4-carbonyl chloride

: 305794-43-8
4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]-1'-(tert-butoxycarbonyl)-4'-methyl-1,4'-bipiperidine

Guidance literature:: Multi-step reaction with 6 steps

1: AlCl₃ / 4 h / Heating

2: p-TsOH / Heating

3: 95 percent / aq. K₂CO₃ / methanol / 20 °C

4: Ti(OiPr)4 / 1,2-dichloro-ethane / 12 h / 20 °C

5: 7.3 g / 3 h / 20 °C

6: 98 percent / MeMgBr / tetrahydrofuran; diethyl ether / 2 h / 20 °C

With titanium(IV) isopropylate; aluminium trichloride; methylmagnesium bromide; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether; 1,2-dichloro-ethane; 1: Friedel-Crafts acylation;
DOI:10.1021/jm0200815