4-(6-(2,4-difluorophenyl)-2,4-dioxo-2H-benzo[e][1,3]oxazin-3(4H)-yl)benzonitrile

Base Information

Chemical Name:4-(6-(2,4-difluorophenyl)-2,4-dioxo-2H-benzo[e][1,3]oxazin-3(4H)-yl)benzonitrile
CAS No.:1468402-99-4
Molecular Formula:C₂₁H₁₀F₂N₂O₃
Molecular Weight:376.319
Hs Code.:

Synonyms:4-(6-(2,4-difluorophenyl)-2,4-dioxo-2H-benzo[e][1,3]oxazin-3(4H)-yl)benzonitrile

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Chemical Property of 4-(6-(2,4-difluorophenyl)-2,4-dioxo-2H-benzo[e][1,3]oxazin-3(4H)-yl)benzonitrile

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Technology Process of 4-(6-(2,4-difluorophenyl)-2,4-dioxo-2H-benzo[e][1,3]oxazin-3(4H)-yl)benzonitrile

There total 4 articles about 4-(6-(2,4-difluorophenyl)-2,4-dioxo-2H-benzo[e][1,3]oxazin-3(4H)-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1468402-87-0
N-(4-cyanophenyl)-2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxamide

: 79-22-1
methyl chloroformate

: 1468402-99-4
4-(6-(2,4-difluorophenyl)-2,4-dioxo-2H-benzo[e][1,3]oxazin-3(4H)-yl)benzonitrile

Guidance literature:: With pyridine; In tetrahydrofuran; at 0 - 20 ℃; for 13h; Reflux;

Reference yield:

: 344348-56-7
C₁₃H₇ClF₂O₂

: 1468402-99-4
4-(6-(2,4-difluorophenyl)-2,4-dioxo-2H-benzo[e][1,3]oxazin-3(4H)-yl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / Reflux

2: pyridine / tetrahydrofuran / 14 h / 0 - 70 °C

With pyridine; In tetrahydrofuran;
DOI:10.1016/j.bmc.2015.06.007

Reference yield:

: 22494-42-4
2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid

: 1468402-99-4
4-(6-(2,4-difluorophenyl)-2,4-dioxo-2H-benzo[e][1,3]oxazin-3(4H)-yl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / tetrahydrofuran / 6 h / Reflux; Inert atmosphere; Dean-Stark

2: tetrahydrofuran / Reflux

3: pyridine / tetrahydrofuran / 14 h / 0 - 70 °C

With pyridine; thionyl chloride; In tetrahydrofuran;
DOI:10.1016/j.bmc.2015.06.007