(Z)-1-(ethoxycarbonyl)-2-<3-<(2-methoxyethoxy)methoxy>phenyl>cyclopropanecarboxylic acid

Base Information

• Chemical Name: (Z)-1-(ethoxycarbonyl)-2-<3-<(2-methoxyethoxy)methoxy>phenyl>cyclopropanecarboxylic acid
• CAS No.: 139461-75-9
• Molecular Formula: C₁₇H₂₂O₇
• Molecular Weight: 338.357
• Mol file: 139461-75-9.mol

Synonyms:(Z)-1-(ethoxycarbonyl)-2-<3-<(2-methoxyethoxy)methoxy>phenyl>cyclopropanecarboxylic acid

Chemical Property of (Z)-1-(ethoxycarbonyl)-2-<3-<(2-methoxyethoxy)methoxy>phenyl>cyclopropanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-1-(ethoxycarbonyl)-2-<3-<(2-methoxyethoxy)methoxy>phenyl>cyclopropanecarboxylic acid

There total 4 articles about (Z)-1-(ethoxycarbonyl)-2-<3-<(2-methoxyethoxy)methoxy>phenyl>cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

diethyl 2-<3-<(2-methoxyethoxy)methoxy>phenyl>cyclopropane-1,1-dicarboxylate (139461-74-8) → (Z)-1-(ethoxycarbonyl)-2-<3-<(2-methoxyethoxy)methoxy>phenyl>cyclopropanecarboxylic acid (139461-75-9)

Guidance literature:

With sodium hydroxide; In ethanol; for 40h; Ambient temperature;

DOI:10.1021/jm00086a009

Reference yield:

meta-hydroxybenzaldehyde (100-83-4) → (Z)-1-(ethoxycarbonyl)-2-<3-<(2-methoxyethoxy)methoxy>phenyl>cyclopropanecarboxylic acid (139461-75-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 70 percent / aq. NaOH, Aliquat 336 / CH₂Cl₂ / Ambient temperature

2: 89 percent / piperidine, acetic acid / toluene / Heating

3: 1.) NaH / 1.) DMSO, RT, 30 min, 2.) THF a) RT, 1 h, b) 50 - 60 deg C, 1 h

4: 95.6 percent / aq. NaOH / ethanol / 40 h / Ambient temperature

With piperidine; sodium hydroxide; Aliquat 336; sodium hydride; acetic acid; In ethanol; dichloromethane; toluene;

DOI:10.1021/jm00086a009

Reference yield:

(3-methoxyethoxymethyloxy)benzaldehyde (139461-72-6) → (Z)-1-(ethoxycarbonyl)-2-<3-<(2-methoxyethoxy)methoxy>phenyl>cyclopropanecarboxylic acid (139461-75-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / piperidine, acetic acid / toluene / Heating

2: 1.) NaH / 1.) DMSO, RT, 30 min, 2.) THF a) RT, 1 h, b) 50 - 60 deg C, 1 h

3: 95.6 percent / aq. NaOH / ethanol / 40 h / Ambient temperature

With piperidine; sodium hydroxide; sodium hydride; acetic acid; In ethanol; toluene;

DOI:10.1021/jm00086a009

upstream raw materials:

diethyl 2-<3-<(2-methoxyethoxy)methoxy>phenyl>cyclopropane-1,1-dicarboxylate

meta-hydroxybenzaldehyde

(3-methoxyethoxymethyloxy)benzaldehyde

diethyl <3-<(2-methoxyethoxy)methoxy>benzal>malonate

Downstream raw materials:

N-<(1,1-dimethylethoxy)carbonyl>-O-<(2-methoxyethoxy)methyl>-(E)-2,3-methano-m-tyrosine ethyl ester

(-)-(Z)-2,3-methano-m-tyrosine

(+)-(E)-2,3-methano-m-tyrosine

(+)-(Z)-2,3-methano-m-tyrosine