FMOC-L-PHE(4-GUANIDINO-BOC2)-OH

Base Information

• Chemical Name: FMOC-L-PHE(4-GUANIDINO-BOC2)-OH
• CAS No.: 187283-25-6
• Molecular Formula: C35H40 N4 O8
• Molecular Weight: 644.71
• Hs Code.: 2925 29 00
• Mol file: 187283-25-6.mol

Synonyms:N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-4-BIS(TERT-BUTYLOXYCARBONYL)GUANIDINO-PHENYLALANINE;FMOC-PHE(4-GUANIDINO-BOC2)-OH;FMOC-L-PHE(4-GUANIDINO-BOC2)-OH;FMOC-PHE(4-BOC(T2)-GUANIDINO)-OH;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-4-BIS(T-BUTYLOXYCARBONYL)GUANIDINO-PHENYLALANINE;N-ALPHA-(9-FLUOROENYLMETHYLOXYCARBONYL)-L-4-BIS(T-BUTYLOXYCARBONYL)GUANIDINO-PHENYLALANINE

Chemical Property of FMOC-L-PHE(4-GUANIDINO-BOC2)-OH

Chemical Property:

• PKA: 3.80±0.10(Predicted)
• PSA: 164.65000
• Density: 1.26g/cm3
• LogP: 7.43060
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Fmoc-Phe(bis-Boc-4-guanidino)-OH Novabiochem? ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-L-PHE(4-GUANIDINO-BOC2)-OH

There total 3 articles about FMOC-L-PHE(4-GUANIDINO-BOC2)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + C20H30N4O6 (187283-26-7) → Fmoc-p-(N,N'-Boc-guanidino)Phe (187283-25-6)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; Ambient temperature;

DOI:10.1016/S0960-894X(98)00730-6

Reference yield:

p-amino-L-phenylalanine hydrochloride (62040-55-5) → Fmoc-p-(N,N'-Boc-guanidino)Phe (187283-25-6)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₃COONa

2: 81 percent / aq. NaHCO₃ / dioxane / Ambient temperature

With sodium acetate; sodium hydrogencarbonate; In 1,4-dioxane;

DOI:10.1016/S0960-894X(98)00730-6

Reference yield:

N,N'-bis-Boc-1-guanylpyrazole → Fmoc-p-(N,N'-Boc-guanidino)Phe (187283-25-6)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₃COONa

2: 81 percent / aq. NaHCO₃ / dioxane / Ambient temperature

With sodium acetate; sodium hydrogencarbonate; In 1,4-dioxane;

DOI:10.1016/S0960-894X(98)00730-6

upstream raw materials:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

C₂₀H₃₀N₄O₆

p-amino-L-phenylalanine hydrochloride

Downstream raw materials:

(S)-2-(2-((S)-1-(((tert-butoxy)carbonyl)amino)-3-methylbutyl)oxazole-4-carboxàmido)-3-(4-guanidinophenyl)propanoic acid

C₂₅H₃₆N₆O₆

Refernces