(-)-O-Desmethylvenlafaxine

Base Information

Chemical Name:(-)-O-Desmethylvenlafaxine
CAS No.:142761-11-3
Molecular Formula:C16H25 N O2
Molecular Weight:263.38
Hs Code.:9999999999
UNII:HY5T9WKI4O
DSSTox Substance ID:DTXSID10162168
Wikidata:Q27280156
Mol file:142761-11-3.mol

Synonyms:(R)-(-)-O-desmethylvenlafaxine;SEP-227162

Suppliers and Price of (-)-O-Desmethylvenlafaxine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
R-(-)-O-DesmethylVenlafaxine
50mg
$ 1455.00

Medical Isotopes, Inc.
R-(-)-O-DesmethylVenlafaxine
25 mg
$ 2200.00

Biosynth Carbosynth
R-(-)-O-Desmethyl venlafaxine
10 mg
$ 495.50

Biosynth Carbosynth
R-(-)-O-Desmethyl venlafaxine
5 mg
$ 272.60

Biosynth Carbosynth
R-(-)-O-Desmethyl venlafaxine
2 mg
$ 149.90

Biosynth Carbosynth
R-(-)-O-Desmethyl venlafaxine
25 mg
$ 901.00

Biosynth Carbosynth
R-(-)-O-Desmethyl venlafaxine
50 mg
$ 1638.00

American Custom Chemicals Corporation
R-(-)-O-DESMETHYLVENLAFAXINE 95.00%
50MG
$ 1963.50

American Custom Chemicals Corporation
R-(-)-O-DESMETHYLVENLAFAXINE 95.00%
5MG
$ 786.50

Total 9 raw suppliers

Chemical Property of (-)-O-Desmethylvenlafaxine

Chemical Property:

Melting Point:208-213℃
Boiling Point:403.8±25.0 °C(Predicted)
PKA:10.04±0.26(Predicted)
PSA：43.70000
Density:1.115±0.06 g/cm3(Predicted)
LogP:2.73260
Storage Temp.:Hygroscopic, -20°C Freezer, Under Inert Atmosphere
XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:263.188529040
Heavy Atom Count:19
Complexity:266

Purity/Quality:

95% ^*data from raw suppliers

R-(-)-O-DesmethylVenlafaxine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O
Isomeric SMILES:CN(C)C[C@@H](C1=CC=C(C=C1)O)C2(CCCCC2)O
Uses A metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant. It can also be used to treat sleep-related breathing disorders. R-(-)-O-DesMethyl Venlafaxine is a metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor,it is used as an antidepressant.

Technology Process of (-)-O-Desmethylvenlafaxine

There total 6 articles about (-)-O-Desmethylvenlafaxine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 142761-11-3
(R)-4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol

Guidance literature:

Reference yield:

: 272788-00-8
1-((R)-2-(dimethylamino)-1-(4-methoxyphenyl)ethyl) cyclohexanol hemi-ditoluoyl tartrate

: 142761-11-3
(R)-4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol

Guidance literature:: 1-((R)-2-(dimethylamino)-1-(4-methoxyphenyl)ethyl) cyclohexanol hemi-ditoluoyl tartrate; With sodium hydroxide; In tert-butyl methyl ether; water;

With lithium diphenylphosphide; In tetrahydrofuran; hexanes; at 60 ℃;

With hydrogenchloride; ammonia; more than 3 stages;

Reference yield:

: 93413-44-6,93413-69-5,131801-71-3,93413-46-8
(R)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol

: 142761-11-3
(R)-4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol

Guidance literature:: (R)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol; With lithium diphenylphosphide; In tetrahydrofuran; at 0 - 20 ℃; Heating / reflux;

With hydrogenchloride; water; In tetrahydrofuran; at 15 ℃; for 0.166667h;

With sodium hydrogencarbonate; In water; pH=6.8 - 6.9; Product distribution / selectivity;