1-chloromethyl-isoquinoline

Base Information

• Chemical Name: 1-chloromethyl-isoquinoline
• CAS No.: 27311-65-5
• Molecular Formula: C₁₀H₈ClN
• Molecular Weight: 177.633
• Mol file: 27311-65-5.mol

Synonyms:1-chloromethyl-isoquinoline

Chemical Property of 1-chloromethyl-isoquinoline

Chemical Property:

• Density: 1.229

Purity/Quality:

99.3% ^*data from raw suppliers

1-Chloromethyl-isoquinoline 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 1-(Chloromethyl)isoquinoline is used as a reactant in the preparation of tetrakis(isoquinolylmethyl)ethylenediamine.

Technology Process of 1-chloromethyl-isoquinoline

There total 3 articles about 1-chloromethyl-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-Hydroxymethyl-isoquinoline (27311-63-3) → 1-chloromethyl-isoquinoline (27311-65-5)

Guidance literature:

1-Hydroxymethyl-isoquinoline; With thionyl chloride; In chloroform; at 0 ℃; for 0.5h;

With ammonia; water; In chloroform; at 0 ℃; for 0.5h;

Reference yield: 72.0%

1-methylisoquinoline (1721-93-3) → 1-chloromethyl-isoquinoline (27311-65-5)

Guidance literature:

With N-chloro-succinimide; N-hydroxyphthalimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In acetonitrile; at 80 ℃; for 3h; Sealed tube; Inert atmosphere;

DOI:10.1039/c9ob00216b

Reference yield: 20.0%

1-methylisoquinoline (1721-93-3) → 1-chloromethyl-isoquinoline (27311-65-5) + 1-dichloromethylisoquinoline (88237-16-5)

Guidance literature:

With N-chloro-succinimide; Perbenzoic acid; In tetrachloromethane; for 24h; Heating;

DOI:10.1055/s-1984-30930

upstream raw materials:

1-methylisoquinoline

1-Hydroxymethyl-isoquinoline

Downstream raw materials:

tris(1-isoquinolylmethyl)amine

[(isoquinolin-1-yl)methyl]amine

Refernces

• 1、 -. "BIS1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR USES AS PHARMACEUTICALS". Page/Page column 7-8. . Retrieved 2009/04/24.
• 2、 Newkome, George R.,Kiefer, Garry E.,Yuan-Jiao Xia,Gupta, Vinod K.. "-Methyl Functionalization of Electron-Poor Heterocycles: Free Radical Chlorination". . p. 676 - 679. Retrieved 2007/10/02.