27311-63-3

Basic information

• Product Name: 1-ISOQUINOLINEMETHANOL
• Synonyms: IFLAB-BB F2124-0014;AKOS BBS-00000365;1-ISOQUINOLINEMETHANOL;1-ISOQUINOLINYLMETHANOL;1-(Hydroxymethyl)isoquinoline;1-ISOPROPYLADAMANTANE;isoquinolin-1-ylMethanol;(Isoquinolin-1-yl)methanol, 1-(Hydroxymethyl)-2-azanaphthalene
• CAS NO: 27311-63-3
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18
• Mol File: 27311-63-3.mol
• Article Data: 13

Chemical Properties

• Melting Point: 80℃
• Boiling Point: 335.1 °C at 760 mmHg
• Flash Point: 156.5 °C
• Appearance: /
• Density: 1.218 g/cm³
• Vapor Pressure: 4.82E-05mmHg at 25°C
• Refractive Index: 1.667
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.48±0.10(Predicted)
• CAS DataBase Reference: 1-ISOQUINOLINEMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ISOQUINOLINEMETHANOL(27311-63-3)
• EPA Substance Registry System: 1-ISOQUINOLINEMETHANOL(27311-63-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 27311-63-3(Hazardous Substances Data)

Usage

General Description

1-Isoquinolinemethanol, also known by its systematic name as 1-(Hydroxymethyl)isoquinoline, is a chemical compound with the molecular formula C10H9NO. It's an organic compound that falls under the category of isoquinolines. 1-Isoquinolinemethanol is soluble in water, and it appears as a crystalline solid. The properties of this compound make it useful in various applications such as chemical synthesis, pharmaceutical, and biochemical research. 1-Isoquinolinemethanol needs to be handled carefully as it can be harmful if ingested or if it comes in contact with the skin or eyes.

InChI:InChI=1/C10H9NO/c12-7-10-9-4-2-1-3-8(9)5-6-11-10/h1-6,12H,7H2

Upstream product

• 50458-78-1 ethyl isoquinoline-1-carboxylate 
• 27104-72-9 methyl isoquinoline-1-carboxylate 
• 119-65-3 isoquinoline 
• 67-56-1 methanol 
• 109-99-9 tetrahydrofuran 
• 50-00-0 formaldehyd 
• 844-25-7 2-benzoyl-1-cyano-1,2-dihydroisoquinoline 
• 486-73-7 1-isoquinolinecarboxylic acid 
• 107-21-1 ethylene glycol 
• 34456-69-4 [1,2,3]triazolo[5,1-a]isoquinoline 
• 4494-18-2 isoquinoline-1-carbaldehyde 

Downstream Products

• 1721-93-3 1-methylisoquinoline 
• 27311-65-5 1-chloromethyl-isoquinoline 
• 4494-18-2 isoquinoline-1-carbaldehyde 
• 66948-16-1 rac-2-(isoquinolin-1-yl)-1-phenylethan-2-ol 
• 153758-56-6 (1,2,3,4-tetrahydroisoquinolin-1-yl)methanol 
• 74417-44-0 1-(bromomethyl)isoquinoline 

Relevant articles and documents

PIFA-Mediated Cross-Dehydrogenative Coupling of N-Heteroarenes with Cyclic Ethers: Ethanol as an Efficient Promoter

Ethanol is typically used in organic synthesis as an environmentally benign solvent. Herein, we report a mild and efficient cross-dehydrogenative coupling (CDC) reaction of N-heteroarenes with cyclic ethers by uncovering the new reactivity of ethanol as an efficient promoter in PIFA-mediated radical process. The reaction proceeds smoothly under the irradiation of visible light and features excellent functional group compatibility, which allows the expedite synthesis of a variety of medicinally valuable Cα-heteroarylated cyclic ethers in moderate to high yields.

Stereospecific synthesis of a 1β-methylcarbapenem intermediate

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INHIBITORS OF MLH1 AND/OR PMS2 FOR CANCER TREATMENT

The present invention relates to compounds of Formula (I) that target the MLH1 and/or PMS2 proteins that are components of the DNA Mismatch Repair (MMR) process: Formula (I) wherein R1, R2, R3, R4, R6