6-[10-bromo-6-(tert-butyldimethylsilyloxy)-2-methoxy-4-methyl-deca-3,7,9-trienyl]-2-[2-(3,4-dimethoxybenzyloxy)-1-methyl-ethyl]-2-methoxy-5-methyl-tetrahydro-pyran-4-ol

Base Information

Chemical Name:6-[10-bromo-6-(tert-butyldimethylsilyloxy)-2-methoxy-4-methyl-deca-3,7,9-trienyl]-2-[2-(3,4-dimethoxybenzyloxy)-1-methyl-ethyl]-2-methoxy-5-methyl-tetrahydro-pyran-4-ol
CAS No.:889454-56-2
Molecular Formula:C₃₇H₆₁BrO₈Si
Molecular Weight:741.876
Hs Code.:

6-[10-bromo-6-(tert-butyldimethylsilyloxy)-2-methoxy-4-methyl-deca-3,7,9-trienyl]-2-[2-(3,4-dimethoxybenzyloxy)-1-methyl-ethyl]-2-methoxy-5-methyl-tetrahydro-pyran-4-ol

Synonyms:6-[10-bromo-6-(tert-butyldimethylsilyloxy)-2-methoxy-4-methyl-deca-3,7,9-trienyl]-2-[2-(3,4-dimethoxybenzyloxy)-1-methyl-ethyl]-2-methoxy-5-methyl-tetrahydro-pyran-4-ol

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Chemical Property of 6-[10-bromo-6-(tert-butyldimethylsilyloxy)-2-methoxy-4-methyl-deca-3,7,9-trienyl]-2-[2-(3,4-dimethoxybenzyloxy)-1-methyl-ethyl]-2-methoxy-5-methyl-tetrahydro-pyran-4-ol

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Technology Process of 6-[10-bromo-6-(tert-butyldimethylsilyloxy)-2-methoxy-4-methyl-deca-3,7,9-trienyl]-2-[2-(3,4-dimethoxybenzyloxy)-1-methyl-ethyl]-2-methoxy-5-methyl-tetrahydro-pyran-4-ol

There total 10 articles about 6-[10-bromo-6-(tert-butyldimethylsilyloxy)-2-methoxy-4-methyl-deca-3,7,9-trienyl]-2-[2-(3,4-dimethoxybenzyloxy)-1-methyl-ethyl]-2-methoxy-5-methyl-tetrahydro-pyran-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 889454-40-4
(2R,5S,6R,7S,9S,10E,13R,14E,16E)-13-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxybenzyloxy)-17-bromo-5-hydroxy-9-methoxy-7-triethylsilyloxy-2,6,11-trimethyl-heptadeca-10,14,16-trien-3-one

: 149-73-5
trimethyl orthoformate

: 889454-56-2
6-[10-bromo-6-(tert-butyldimethylsilyloxy)-2-methoxy-4-methyl-deca-3,7,9-trienyl]-2-[2-(3,4-dimethoxybenzyloxy)-1-methyl-ethyl]-2-methoxy-5-methyl-tetrahydro-pyran-4-ol

Guidance literature:: With pyridinium p-toluenesulfonate; In methanol; at 20 ℃; for 1h;
DOI:10.1021/ol060609q

Reference yield:

: 889454-41-5
(R)-3-(3,4-dimethoxybenzyloxy)-2-methylbutan-3-one

: 889454-56-2
6-[10-bromo-6-(tert-butyldimethylsilyloxy)-2-methoxy-4-methyl-deca-3,7,9-trienyl]-2-[2-(3,4-dimethoxybenzyloxy)-1-methyl-ethyl]-2-methoxy-5-methyl-tetrahydro-pyran-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 120 mg / triethylamine; dicyclohexylboron chloride / diethyl ether / 17 h / -78 - -27 °C

2: 78 percent / PPTS / methanol / 1 h / 20 °C

With dicyclohexylboron chloride; pyridinium p-toluenesulfonate; triethylamine; In methanol; diethyl ether;
DOI:10.1021/ol060609q

Reference yield:

: 889454-43-7
(6E,10E,12E)-(2S,3S,5S,9R)-13-Bromo-9-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-2,7-dimethyl-3-triethylsilanyloxy-trideca-6,10,12-trienal

: 889454-56-2
6-[10-bromo-6-(tert-butyldimethylsilyloxy)-2-methoxy-4-methyl-deca-3,7,9-trienyl]-2-[2-(3,4-dimethoxybenzyloxy)-1-methyl-ethyl]-2-methoxy-5-methyl-tetrahydro-pyran-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 120 mg / triethylamine; dicyclohexylboron chloride / diethyl ether / 17 h / -78 - -27 °C

2: 78 percent / PPTS / methanol / 1 h / 20 °C

With dicyclohexylboron chloride; pyridinium p-toluenesulfonate; triethylamine; In methanol; diethyl ether;
DOI:10.1021/ol060609q