N¹-benzyl-N⁵-(tert-butoxycarbonyl)-N¹-(3-phthaloylpropyl)-1,5-diaminopentane

Base Information

• Chemical Name: N¹-benzyl-N⁵-(tert-butoxycarbonyl)-N¹-(3-phthaloylpropyl)-1,5-diaminopentane
• CAS No.: 122631-99-6
• Molecular Formula: C₂₈H₃₇N₃O₄
• Molecular Weight: 479.619
• Mol file: 122631-99-6.mol

Synonyms:N¹-benzyl-N⁵-(tert-butoxycarbonyl)-N¹-(3-phthaloylpropyl)-1,5-diaminopentane

Chemical Property of N¹-benzyl-N⁵-(tert-butoxycarbonyl)-N¹-(3-phthaloylpropyl)-1,5-diaminopentane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹-benzyl-N⁵-(tert-butoxycarbonyl)-N¹-(3-phthaloylpropyl)-1,5-diaminopentane

There total 5 articles about N¹-benzyl-N⁵-(tert-butoxycarbonyl)-N¹-(3-phthaloylpropyl)-1,5-diaminopentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.1%

2-(3-bromopropyl)isoindole-1,3-dione (5460-29-7) + N1-benzyl-N5-(tert-butoxycarbonyl)-1,5-diaminopentane (122631-98-5) → N1-benzyl-N5-(tert-butoxycarbonyl)-N1-(3-phthaloylpropyl)-1,5-diaminopentane (122631-99-6)

Guidance literature:

With potassium fluoride; Celite; In acetonitrile; for 15h; Heating;

DOI:10.1023/A:1011988317683

Reference yield:

5-tert-butoxycarbonylamino-1-aminopentane (51644-96-3) → N1-benzyl-N5-(tert-butoxycarbonyl)-N1-(3-phthaloylpropyl)-1,5-diaminopentane (122631-99-6)

Guidance literature:

Multi-step reaction with 3 steps

1: MgSO₄ / methanol / 3 h

2: NaBH₄ / methanol / 19 h / Heating

3: 83.1 percent / 50 percent KF/Celite / acetonitrile / 15 h / Heating

With potassium fluoride; sodium tetrahydroborate; Celite; magnesium sulfate; In methanol; acetonitrile; 1: Condensation / 2: Reduction / 3: Alkylation;

DOI:10.1023/A:1011988317683

Reference yield:

benzaldehyde (100-52-7) → N1-benzyl-N5-(tert-butoxycarbonyl)-N1-(3-phthaloylpropyl)-1,5-diaminopentane (122631-99-6)

Guidance literature:

Multi-step reaction with 3 steps

1: MgSO₄ / methanol / 3 h

2: NaBH₄ / methanol / 19 h / Heating

3: 83.1 percent / 50 percent KF/Celite / acetonitrile / 15 h / Heating

With potassium fluoride; sodium tetrahydroborate; Celite; magnesium sulfate; In methanol; acetonitrile; 1: Condensation / 2: Reduction / 3: Alkylation;

DOI:10.1023/A:1011988317683

upstream raw materials:

2-(3-bromopropyl)isoindole-1,3-dione

N¹-benzyl-N⁵-(tert-butoxycarbonyl)-1,5-diaminopentane

5-tert-butoxycarbonylamino-1-aminopentane

benzaldehyde

Downstream raw materials:

Argiotoxin 659

C₆₄H₈₄N₁₀O₁₁

C₅₉H₇₆N₁₀O₉

C₆₀H₇₈N₈O₉