7-amino-6-(4-chloro-phenyl)-4,5-dihydro-3,9-dithia-10-aza-dicyclopenta[a,g]naphthalene-8-carbonitrile

Base Information

• Chemical Name: 7-amino-6-(4-chloro-phenyl)-4,5-dihydro-3,9-dithia-10-aza-dicyclopenta[a,g]naphthalene-8-carbonitrile
• CAS No.: 251539-12-5
• Molecular Formula: C₂₀H₁₂ClN₃S₂
• Molecular Weight: 393.92

Synonyms:7-amino-6-(4-chloro-phenyl)-4,5-dihydro-3,9-dithia-10-aza-dicyclopenta[a,g]naphthalene-8-carbonitrile

Chemical Property of 7-amino-6-(4-chloro-phenyl)-4,5-dihydro-3,9-dithia-10-aza-dicyclopenta[a,g]naphthalene-8-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 7-amino-6-(4-chloro-phenyl)-4,5-dihydro-3,9-dithia-10-aza-dicyclopenta[a,g]naphthalene-8-carbonitrile

There total 4 articles about 7-amino-6-(4-chloro-phenyl)-4,5-dihydro-3,9-dithia-10-aza-dicyclopenta[a,g]naphthalene-8-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-(4-chloro-phenyl)-2-cyanomethylsulfanyl-5,6-dihydro-thieno[2,3-h]quinoline-3-carbonitrile (251539-06-7) → 7-amino-6-(4-chloro-phenyl)-4,5-dihydro-3,9-dithia-10-aza-dicyclopenta[a,g]naphthalene-8-carbonitrile (251539-12-5)

Guidance literature:

With sodium ethanolate; In ethanol; for 1h; Heating;

DOI:10.1080/10426509908037011

Reference yield:

4-chlorobenzaldehyde (104-88-1) → 7-amino-6-(4-chloro-phenyl)-4,5-dihydro-3,9-dithia-10-aza-dicyclopenta[a,g]naphthalene-8-carbonitrile (251539-12-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 54 percent / NaOH / ethanol / 2 h

2: 42 percent / NaOMe / methanol / 6 h / 50 °C

3: AcONa / ethanol / 2 h / Heating

4: 76 percent / EtONa / ethanol / 1 h / Heating

With sodium hydroxide; sodium methylate; sodium ethanolate; sodium acetate; In methanol; ethanol; 1: Condensation / 2: Condensation / 3: Alkylation / 4: Cyclization;

DOI:10.1080/10426509908037011

Reference yield:

5-(4-chlorobenzylidene)-6,7-dihydrobenz[b]thiophen-4-one (251538-99-5) → 7-amino-6-(4-chloro-phenyl)-4,5-dihydro-3,9-dithia-10-aza-dicyclopenta[a,g]naphthalene-8-carbonitrile (251539-12-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 42 percent / NaOMe / methanol / 6 h / 50 °C

2: AcONa / ethanol / 2 h / Heating

3: 76 percent / EtONa / ethanol / 1 h / Heating

With sodium methylate; sodium ethanolate; sodium acetate; In methanol; ethanol; 1: Condensation / 2: Alkylation / 3: Cyclization;

DOI:10.1080/10426509908037011

upstream raw materials:

4-(4-chloro-phenyl)-2-cyanomethylsulfanyl-5,6-dihydro-thieno[2,3-h]quinoline-3-carbonitrile

4-chlorobenzaldehyde

5-(4-chlorobenzylidene)-6,7-dihydrobenz[b]thiophen-4-one

3-cyano-4-(4-chlorophenyl)-5,6-dihydrothieno[2,3-h]quinolin-2(1H)-thione

Downstream raw materials:

3-amino-12-(4-chlorophenyl)-4-imino-10,11-dihydropyrimido[4',5':4,5]thieno[2,3-b]thieno[2,3-h]quinoline

4-(4-chlorophenyl)-2-cyano-3-ethoxymethyleneamino-5,6-dihydrothieno[2,3-b]thieno[2,3-h]quinoline

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